Cyclins and cyclin-dependent kinases: from biology to tumorigenesis and therapeutic opportunities
The discussion on cell proliferation cannot be continued without taking a look at the cell
cycle regulatory machinery. Cyclin-dependent kinases (CDKs), cyclins, and CDK inhibitors …
cycle regulatory machinery. Cyclin-dependent kinases (CDKs), cyclins, and CDK inhibitors …
[HTML][HTML] The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest
W Zhao, L Zhang, Y Zhang, Z Jiang, H Lu, Y Xie… - Cell Death & …, 2023 - nature.com
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor with a poor median
survival of less than 15 months. However, clinical strategies and effective therapies are …
survival of less than 15 months. However, clinical strategies and effective therapies are …
Cdk2 suppresses IL‐23 expression and the onset of severe acute pancreatitis
Y Ma, L Liu, B Li, W Wang… - Immunity, Inflammation and …, 2022 - Wiley Online Library
Background Acute pancreatitis is a sudden inflammation of the pancreas. Although
interleukin‐23 (IL‐23) is associated with the severity of acute pancreatitis, the underlying …
interleukin‐23 (IL‐23) is associated with the severity of acute pancreatitis, the underlying …