The interior of a living cell is a crowded, heterogenuous, fluctuating environment. Hence, a
major challenge in modeling intracellular transport is to analyze stochastic processes within …

The question about the origin of life often appears as a question about" cause and effect".
Physical theories of macroscopic processes usually involve answers to such questions …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

The very high concentration of macromolecules within cells can potentially have an
overwhelming effect on the thermodynamic activity of cellular components because of …

The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …

A model based on DNA methylation is proposed to explain the initiation and maintenance of
mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell …

Although the importance of the polyelectrolyte character of DNA has been recognized for
some time (Felsenfeld & Miles 1967), few of the implications have been explored, primarily …

The gel electrophoresis mobility shift assay (EMSA) is used to detect protein complexes with
nucleic acids. It is the core technology underlying a wide range of qualitative and …

Otto G. Berg, 1 Robert B. Winter, 8 and Peter H. von Hippel** abstract: Genome regulatory
proteins (eg, repressors or polymerases) that function by binding to specific chromosomal …

This review examines intermittent target search strategies, which combine phases of slow
motion, allowing the searcher to detect the target, and phases of fast motion during which …