Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment
Hepatic fibrosis/cirrhosis is a significant health burden worldwide, resulting in liver failure or
hepatocellular carcinoma (HCC) and accounting for many deaths each year. The …
hepatocellular carcinoma (HCC) and accounting for many deaths each year. The …
[HTML][HTML] Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
Natural ageing of organisms and corresponding age-related diseases result mainly from
stem cell ageing and “inflammaging”. Mesenchymal stem cells (MSCs) exhibit very high …
stem cell ageing and “inflammaging”. Mesenchymal stem cells (MSCs) exhibit very high …
[HTML][HTML] The use of heparin/polycation coacervate sustain release system to compare the bone regenerative potentials of 5 BMPs using a critical sized calvarial bone …
Nonunion following bone fracture and segmental bone defects are challenging clinical
conditions. To combat this clinical dilemma, development of new bone tissue engineering …
conditions. To combat this clinical dilemma, development of new bone tissue engineering …
[HTML][HTML] Aging and mesenchymal stem cells: therapeutic opportunities and challenges in the older group
H Chen, O Liu, S Chen, Y Zhou - Gerontology, 2022 - karger.com
With aging, a portion of cells, including mesenchymal stem cells (MSCs), become
senescent, and these senescent cells accumulate and promote various age-related …
senescent, and these senescent cells accumulate and promote various age-related …
[HTML][HTML] Efficacy and safety of stem cell therapy for the early-stage osteonecrosis of femoral head: a systematic review and meta-analysis of randomized controlled …
L Mao, P Jiang, X Lei, C Ni, Y Zhang, B Zhang… - Stem cell research & …, 2020 - Springer
Background Osteonecrosis of femoral head (ONFH) is a seriously degenerative disease with
no effective therapies to slow its progression. Several studies have reported short-term …
no effective therapies to slow its progression. Several studies have reported short-term …
[HTML][HTML] Essential roles of the dystrophin-glycoprotein complex in different cardiac pathologies
IC Valera, AL Wacker, HS Hwang, C Holmes… - Advances in medical …, 2021 - Elsevier
The dystrophin-glycoprotein complex (DGC), situated at the sarcolemma dynamically
remodels during cardiac disease. This review examines DGC remodeling as a common …
remodels during cardiac disease. This review examines DGC remodeling as a common …
Injectable BMP-2 gene-activated scaffold for the repair of cranial bone defect in mice
Tissue engineering using adult human mesenchymal stem cells (MSCs) seeded within
biomaterial scaffolds has shown the potential to enhance bone healing. Recently, we have …
biomaterial scaffolds has shown the potential to enhance bone healing. Recently, we have …
A Senomorphic‐Conjugated Scaffold for Application of Senescent Cells in Regenerative Medicine
W Deng, J Jo, T Tanaka, H Morikuni… - Advanced …, 2023 - Wiley Online Library
Procuring a sufficient amount of cells is essential for cell‐based regenerative therapy.
However, the application of senescent cells replicated using cell culture is limited because …
However, the application of senescent cells replicated using cell culture is limited because …
[HTML][HTML] β-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model
Fractures continue to be a global economic burden as there are currently no osteoanabolic
drugs approved to accelerate fracture healing. In this study, we aimed to develop an …
drugs approved to accelerate fracture healing. In this study, we aimed to develop an …
[HTML][HTML] Stem cells and bone tissue engineering
Segmental bone defects that are caused by trauma, infection, tumor resection, or
osteoporotic fractures present significant surgical treatment challenges. Host bone autograft …
osteoporotic fractures present significant surgical treatment challenges. Host bone autograft …