Emerging role of exosomal microRNA in liver cancer in the era of precision medicine; potential and challenges

T El Hayek, OA Alnaser-Almusa… - Frontiers in Molecular …, 2024 - frontiersin.org
Exosomal microRNAs (miRNAs) have great potential in the fight against hepatocellular
carcinoma (HCC), the fourth most common cause of cancer-related death worldwide. In this …

Unraveling the Janus-Faced Role of Autophagy in Hepatocellular Carcinoma: Implications for Therapeutic Interventions

TH Nguyen, TM Nguyen, DTM Ngoc, T You… - International Journal of …, 2023 - mdpi.com
This review aims to provide a comprehensive understanding of the molecular mechanisms
underlying autophagy and mitophagy in hepatocellular carcinoma (HCC). Autophagy is an …

Comparative Analysis of Atezolizumab Plus Bevacizumab and Hepatic Artery Infusion Chemotherapy in Unresectable Hepatocellular Carcinoma: A Multicenter …

JH Kim, HC Nam, CW Kim, HS Cho, JS Yoo, JW Han… - Cancers, 2023 - mdpi.com
Simple Summary We aimed to compare the prognosis of patients with advanced
hepatocellular carcinoma treated with the first-line atezolizumab plus bevacizumab (AB) …

A nationwide study on the current treatment status and natural prognosis of hepatocellular carcinoma in elderly

JJ Yoo, J Lee, GH Choi, MW Lee, DA Park - Scientific Reports, 2023 - nature.com
The aim of this study was to identify the treatment status and natural prognosis of
hepatocellular carcinoma (HCC) patients aged 65 years or older in Korea. We analyzed …

Smoking increases the risk of hepatocellular carcinoma and cardiovascular disease in patients with metabolic-associated fatty liver disease

JJ Yoo, MY Park, EJ Cho, SJ Yu, SG Kim… - Journal of Clinical …, 2023 - mdpi.com
The association of smoking with hepatocellular carcinoma (HCC) or cardiovascular disease
(CVD) has been reported, but the study of its relationship with metabolic-associated fatty …

Validation of MELD 3.0 scoring system in East Asian patients with cirrhosis awaiting liver transplantation

JJ Yoo, JI Chang, JE Moon, DH Sinn, SG Kim… - Liver …, 2023 - journals.lww.com
Recently, a new predictive model that jointly considers the Model of End-stage Liver
Disease (MELD) 3.0 and albumin has been proposed. This study investigated the …

[HTML][HTML] NAFLD-associated Hepatocellular Carcinoma (HCC)–a compelling case for repositioning of existing mTORc1 inhibitors

N Sharma, L Singh, A Sharma, A Kumar… - Pharmacological …, 2024 - Elsevier
The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) is a growing concern
for the high incidence rate of hepatocellular carcinoma (HCC) globally. The progression of …

[HTML][HTML] Surgical Implications for Nonalcoholic Steatohepatitis-Related Hepatocellular Carcinoma

CR Anbarasu, S Williams-Perez, ER Camp, DJ Erstad - Cancers, 2024 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is an aggressive form of liver cancer that
arises in a background of chronic hepatic injury. Metabolic syndrome-associated fatty liver …

Trends in alcohol use and alcoholic liver disease in South Korea: a nationwide cohort study

JJ Yoo, DH Lee, Y Chang, H Jo, YY Cho, S Lee… - BMC Public Health, 2024 - Springer
Background There is a lack of national-level research on alcohol consumption and the
epidemiology of alcoholic liver disease (ALD) in South Korea. This study aims to address the …

Overnutrition and Lipotoxicity: Impaired Efferocytosis and Chronic Inflammation as Precursors to Multifaceted Disease Pathogenesis

V Mann, A Sundaresan, S Shishodia - Biology, 2024 - mdpi.com
Simple Summary Overnutrition, characterized by an excessive caloric intake, often leads to
lipotoxicity, a condition where lipids accumulate abnormally in non-adipose tissues. This …