Epidemic diseases and antibiotic resistance are urgent threats to global health, and human
is confronted with an unprecedented dilemma to conquer them by expediting development …

Lethal mutagenesis has emerged as a novel potential therapeutic approach to treat viral
infections. Several studies have demonstrated that increases in the high mutation rates …

Antibiotic-resistant pathogens often escape antimicrobial treatment by forming protective
biofilms in response to quorum-sensing communication via diffusible autoinducers. Biofilm …

Formycin A is a potent purine nucleoside antibiotic with a C-glycosidic linkage between the
ribosyl moiety and the pyrazolopyrimidine base. Herein, a cosmid is identified from the …

C‐Nucleosides are characterized by a C− C rather than a C− N linkage between the
heterocyclic base and the ribofuranose ring. While the biosynthesis of pseudouridine‐C …

Abstract Nitrogen‐Nitrogen (N− N) bond‐containing functional groups in natural products
and synthetic drugs play significant roles in exerting biological activities. The mechanisms of …

Hepatitis E is a global public health problem. Ribavirin (RBV) and pegylated interferon alpha
are currently administered to cure hepatitis E. Recently, in combination with RBV, sofosbuvir …

A biomass-derived platform chemical was utilized to access a demanded pharmaceutical
substance with anti-HIV activity (HIV, human immunodeficiency virus) and a variety of …

ABSTRACT Human immunodeficiency virus-1 (HIV-1) encodes a transcriptional factor called
Tat, which is critical for viral transcription. Tat-mediated transcription is highly ordered apart …

Genome scanning of Streptomyces kaniharaensis, the producer of formycin A, reveals two
sets of purA, purB, purC, and purH genes. The Pur enzymes catalyze pyrimidine assembly of …