Human placenta and trophoblast development: key molecular mechanisms and model systems

M Knöfler, S Haider, L Saleh, J Pollheimer… - Cellular and Molecular …, 2019 - Springer
Abnormal placentation is considered as an underlying cause of various pregnancy
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …

Regulation of placental extravillous trophoblasts by the maternal uterine environment

J Pollheimer, S Vondra, J Baltayeva… - Frontiers in …, 2018 - frontiersin.org
During placentation invasive extravillous trophoblasts (EVTs) migrate into the maternal
uterus and modify its vessels. In particular, remodeling of the spiral arteries by EVTs is …

Practical guidance for the evaluation and management of drug hypersensitivity: specific drugs

AD Broyles, A Banerji, S Barmettler, CM Biggs… - The Journal of Allergy …, 2020 - Elsevier
Allergists and clinical immunologists around the world are increasingly faced with the task of
addressing drug allergy and hypersensitivity due to the increase in drug reactions …

Transforming growth factor-β signaling governs the differentiation program of extravillous trophoblasts in the developing human placenta

S Haider, AI Lackner, B Dietrich… - Proceedings of the …, 2022 - National Acad Sciences
Abnormal placentation has been noticed in a variety of pregnancy complications such as
miscarriage, early-onset preeclampsia, and fetal growth restriction. Defects in the …

WNT and NOTCH signaling in human trophoblast development and differentiation

B Dietrich, S Haider, G Meinhardt, J Pollheimer… - Cellular and Molecular …, 2022 - Springer
Correct development of the human placenta and its differentiated epithelial cells, syncytial
trophoblasts (STBs) and extravillous trophoblasts (EVTs), is crucial for a successful …

[HTML][HTML] Placenta-derived extracellular vesicles induce preeclampsia in mouse models

C Han, C Wang, Y Chen, J Wang, X Xu, T Hilton… - …, 2020 - ncbi.nlm.nih.gov
Preeclampsia is a pregnancy-induced condition that impairs the mother's health and results
in pregnancy termination or premature delivery. Elevated levels of placenta-derived …

The roles of free iron, heme, haemoglobin, and the scavenger proteins haemopexin and alpha‐1‐microglobulin in preeclampsia and fetal growth restriction

L Erlandsson, Z Masoumi, LR Hansson… - Journal of internal …, 2021 - Wiley Online Library
Background Preeclampsia (PE) is a complex pregnancy syndrome characterised by
maternal hypertension and organ damage after 20 weeks of gestation and is associated with …

Circular RNA circ_0111277 attenuates human trophoblast cell invasion and migration by regulating miR-494/HTRA1/Notch-1 signal pathway in pre-eclampsia

Y Ou, L Zhu, X Wei, S Bai, M Chen, H Chen… - Cell death & …, 2020 - nature.com
Mounting evidence has revealed that impaired spiral artery remodeling, placental
dysfunction, and inadequate trophoblast invasion are closely correlated with the etiology …

The effect of endocrine-disrupting chemicals on placental development

Y Yan, F Guo, K Liu, R Ding, Y Wang - Frontiers in endocrinology, 2023 - frontiersin.org
Endocrine-disrupting chemicals (EDCs) or endocrine disruptors are substances that are
either naturally occurring or artificial and are released into the natural environment. Humans …

Syncytiotrophoblast-derived extracellular vesicles in pathophysiology of preeclampsia

C Han, L Han, P Huang, Y Chen, Y Wang… - Frontiers in …, 2019 - frontiersin.org
Preeclampsia is a common obstetric complication associated with pregnancy and it
endangers lives of the mother and the infant. The histopathological changes associated with …