The human connectome in Alzheimer disease—relationship to biomarkers and genetics

M Yu, O Sporns, AJ Saykin - Nature Reviews Neurology, 2021 - nature.com
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

Models of network spread and network degeneration in brain disorders

A Raj, F Powell - Biological Psychiatry: Cognitive Neuroscience and …, 2018 - Elsevier
Network analysis can provide insight into key organizational principles of brain structure and
help identify structural changes associated with brain disease. Though static differences …

Diffusion MRI indices and their relation to cognitive impairment in brain aging: the updated multi-protocol approach in ADNI3

A Zavaliangos-Petropulu, TM Nir… - Frontiers in …, 2019 - frontiersin.org
Brain imaging with diffusion-weighted MRI (dMRI) is sensitive to microstructural white matter
(WM) changes associated with brain aging and neurodegeneration. In its third phase, the …

[HTML][HTML] Network model of pathology spread recapitulates neurodegeneration and selective vulnerability in Huntington's disease

A Raj, F Powell - NeuroImage, 2021 - Elsevier
Abstract Huntington's Disease (HD), an autosomal dominant genetic disorder caused by a
mutation in the Huntingtin gene (HTT), displays a stereotyped topography in the human …

[HTML][HTML] Molecular and microstructural biomarkers of neuroplasticity in neurodegenerative disorders through preclinical and diffusion magnetic resonance imaging …

RG Gatto - Journal of Integrative Neuroscience, 2020 - imrpress.com
Advances in the understanding of genetic and molecular mechanisms and imaging
technologies have opened a new window of research possibilities to address dynamic …

Graph models of pathology spread in Alzheimer's disease: an alternative to conventional graph theoretic analysis

A Raj - Brain connectivity, 2021 - liebertpub.com
Background: Graph theory and connectomics are new techniques for uncovering disease-
induced changes in the brain's structural network. Most prior studied have focused on …

Combined model of aggregation and network diffusion recapitulates Alzheimer's regional tau-positron emission tomography

A Raj, V Tora, X Gao, H Cho, JY Choi, YH Ryu… - Brain …, 2021 - liebertpub.com
Background: Alzheimer's disease involves widespread and progressive deposition of
misfolded protein tau (τ), first appearing in the entorhinal cortex, coagulating in longer …

[HTML][HTML] Hierarchical complexity of the adult human structural connectome

K Smith, ME Bastin, SR Cox, MCV Hernández… - Neuroimage, 2019 - Elsevier
The structural network of the human brain has a rich topology which many have sought to
characterise using standard network science measures and concepts. However, this …

Differences in topological progression profile among neurodegenerative diseases from imaging data

S Garbarino, M Lorenzi, NP Oxtoby, EJ Vinke… - Elife, 2019 - elifesciences.org
The spatial distribution of atrophy in neurodegenerative diseases suggests that brain
connectivity mediates disease propagation. Different descriptors of the connectivity graph …

Combining multimodal connectivity information improves modelling of pathology spread in Alzheimer's disease

E Thompson, A Schroder, T He, C Shand… - Imaging …, 2024 - direct.mit.edu
Cortical atrophy and aggregates of misfolded tau proteins are key hallmarks of Alzheimer's
disease. Computational models that simulate the propagation of pathogens between …