The human connectome in Alzheimer disease—relationship to biomarkers and genetics
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …
resulting in cognitive impairment. The results of recent connectomics studies have now …
Models of network spread and network degeneration in brain disorders
Network analysis can provide insight into key organizational principles of brain structure and
help identify structural changes associated with brain disease. Though static differences …
help identify structural changes associated with brain disease. Though static differences …
Diffusion MRI indices and their relation to cognitive impairment in brain aging: the updated multi-protocol approach in ADNI3
A Zavaliangos-Petropulu, TM Nir… - Frontiers in …, 2019 - frontiersin.org
Brain imaging with diffusion-weighted MRI (dMRI) is sensitive to microstructural white matter
(WM) changes associated with brain aging and neurodegeneration. In its third phase, the …
(WM) changes associated with brain aging and neurodegeneration. In its third phase, the …
[HTML][HTML] Network model of pathology spread recapitulates neurodegeneration and selective vulnerability in Huntington's disease
Abstract Huntington's Disease (HD), an autosomal dominant genetic disorder caused by a
mutation in the Huntingtin gene (HTT), displays a stereotyped topography in the human …
mutation in the Huntingtin gene (HTT), displays a stereotyped topography in the human …
[HTML][HTML] Molecular and microstructural biomarkers of neuroplasticity in neurodegenerative disorders through preclinical and diffusion magnetic resonance imaging …
RG Gatto - Journal of Integrative Neuroscience, 2020 - imrpress.com
Advances in the understanding of genetic and molecular mechanisms and imaging
technologies have opened a new window of research possibilities to address dynamic …
technologies have opened a new window of research possibilities to address dynamic …
Graph models of pathology spread in Alzheimer's disease: an alternative to conventional graph theoretic analysis
A Raj - Brain connectivity, 2021 - liebertpub.com
Background: Graph theory and connectomics are new techniques for uncovering disease-
induced changes in the brain's structural network. Most prior studied have focused on …
induced changes in the brain's structural network. Most prior studied have focused on …
Combined model of aggregation and network diffusion recapitulates Alzheimer's regional tau-positron emission tomography
A Raj, V Tora, X Gao, H Cho, JY Choi, YH Ryu… - Brain …, 2021 - liebertpub.com
Background: Alzheimer's disease involves widespread and progressive deposition of
misfolded protein tau (τ), first appearing in the entorhinal cortex, coagulating in longer …
misfolded protein tau (τ), first appearing in the entorhinal cortex, coagulating in longer …
[HTML][HTML] Hierarchical complexity of the adult human structural connectome
The structural network of the human brain has a rich topology which many have sought to
characterise using standard network science measures and concepts. However, this …
characterise using standard network science measures and concepts. However, this …
Differences in topological progression profile among neurodegenerative diseases from imaging data
The spatial distribution of atrophy in neurodegenerative diseases suggests that brain
connectivity mediates disease propagation. Different descriptors of the connectivity graph …
connectivity mediates disease propagation. Different descriptors of the connectivity graph …
Combining multimodal connectivity information improves modelling of pathology spread in Alzheimer's disease
Cortical atrophy and aggregates of misfolded tau proteins are key hallmarks of Alzheimer's
disease. Computational models that simulate the propagation of pathogens between …
disease. Computational models that simulate the propagation of pathogens between …