Reactive oxygen species derived from NADPH oxidase contribute to a wide variety of renal
diseases. Nox4, the major NADPH isoform in kidney, produces mainly H 2 O 2 that regulates …

The Wnt/β-catenin signaling pathway is an evolutionarily conserved developmental
signaling event that plays a critical role in regulating tissue development and maintaining …

Perfluorooctane sulfonate (PFOS) is one of the persistent organic pollutants (POPs), which
can cause severe nephrotoxicity in mammals. Cannabinol (CBD), a nonpsychoactive …

The goal of this study was to elucidate the functional role of Nox4 during acute kidney injury
(AKI). NADPH oxidases are a major source of reactive oxygen species (ROS) in the kidney …

Rationale: Sepsis is a severe clinical syndrome featured through organ dysfunction due to
infection, while the accompanying acute kidney injury (AKI) is linked to significant incidence …

Doxorubicin (DOX) is a wide spectrum antitumor drug. However, its clinical application is
limited due to the cardiotoxicity. Carvedilol (CAR) is a β-blocker used to treat high blood …

Uncovering new therapeutic targets for renal fibrosis holds promise for the treatment of
chronic kidney diseases. Bromodomain and extra-terminal (BET) protein inhibitors have …

p300/CBP-associated factor (PCAF), a histone acetyltransferase, is involved in many cellular
processes such as differentiation, proliferation, apoptosis, and reaction to cell damage by …

Renal fibrosis is a common feature of chronic kidney disease and is a promising therapeutic
target. However, there is still limited treatment for renal fibrosis, so the development of new …

Indoxyl sulfate (IS), a uremic toxin, causes chronic kidney disease (CKD) progression via
renal fibrosis. Epithelial–mesenchymal transition (EMT) is a crucial feature of renal fibrosis …