Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal
transition, a process that remodels tumor cells increasing their invasion and chemo …

In recent decades, cancer biology and medicine have ushered in a new age of precision
medicine through high-throughput approaches that led to the development of novel targeted …

The SARS-CoV-2 prefusion spike heads (receptor binding domains, RBDs) frequently nod
down and up to interact with host cell receptors. As the spike protein is a trimeric unit of …

Several studies in the last few years have determined that, in contrast to the prevailing
dogma that drug resistance is simply due to Darwinian evolution—the selection of mutant …

Drug resistance remains one of the major impediments to treating cancer. Although many
patients respond well initially, resistance to therapy typically ensues. Several confounding …

Abstract This Commentary describes the June 2022 installment of the “Editors' Roundup”
feature. The Editors' Roundup is a multi-author collective description of recently published …

Chemical conjugation of purified proteins of interest (POIs) in Escherichia coli cells is
effective for high expression but has limitations for highly chromogenic dual labeling of …

Cancer cells, like all other organisms, are adept at switching their phenotype to adjust to the
changes in their environment. Thus, phenotypic plasticity is a quantitative trait that confers a …

Intrinsically disordered proteins (IDPs) have numerous dynamic conformations. Given the
difficulties in tracking temporarily folded states of this kind of protein, methods such as …

The current issue (volume 13 issue 6, 2021) is a Special Issue jointly dedicated to scientific
content presented at the 20th triennial IUPAB Congress that was held in conjunction with …