ATP, the universal energy currency in all living cells, is mainly synthesized in mitochondria
by oxidative phosphorylation (OXPHOS). The final and rate limiting step of the respiratory …

The molecular origin of standard metabolic rate and thermogenesis in mammals is
examined. It is pointed out that there are important differences and distinctions between the …

ROS (superoxide and oxygen peroxide in this paper) play a dual role as signalling
molecules and strong oxidizing agents leading to oxidative stress. Their production mainly …

There is little doubt that the central areas of traditional biochemistry (such as metabolism,
metabolic regulation and enzymology) are currently unfashionable and generally regarded …

There is no doubt that nowadays, biology benefits greatly from mathematics. In particular,
cellular biology is, besides population dynamics, a field where tech niques of mathematical …

In living cells, growth is the result of coupling between substrate catabolism and multiple
metabolic processes that take place during net biomass formation and maintenance …

Germ-line and somatic mtDNA mutations are hypothesized to act together to shape our
history and our health. Germ-line mtDNA mutations, both ancient and recent, have been …

The oxygen affinity of the enzyme system involved in mitochondrial respiration indicates, in
relation to intracellular oxygen levels and interpreted with the aid of flux control analysis, a …

Mitochondrial cytopathies present a tissue specificity characterized by the fact that even if a
mitochondrial DNA mutation is present in all tissues, only some will be affected and induce a …

A new mechanism on regulation of mitochondrial energy metabolism is proposed on the
basis of reversible control of respiration by the intramitochondrial ATP/ADP ratio and slip of …