The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

Troponin is a heterotrimeric Ca 2+-binding protein that has a well-established role in
regulating striated muscle contraction. However, mounting evidence points to novel cellular …

The protein sarcospan (SSPN) is an integral member of the dystrophin-glycoprotein complex
(DGC) and has been shown to be important in the heart during the development and the …

Mutations in thin filament regulatory proteins that cause hypertrophic cardiomyopathy (HCM)
increase myofilament Ca 2+ sensitivity. Mouse models exhibit increased Ca 2+ buffering …

Inherited cardiac diseases comprise a wide and heterogeneous spectrum of diseases of the
heart, including the cardiomyopathies and the arrhythmic diseases in structurally normal …

Introduction Troponin (TNN)-encoded cardiac troponins (Tn) are critical for sensing calcium
and triggering myofilament contraction. TNN variants are associated with development of …

Abstract Treatment for heart disease, the leading cause of death in the world, has
progressed little for several decades. Here we develop a protein engineering approach to …

Hypertrophic cardiomyopathy (HCM) is triggered mainly by mutations in genes encoding
sarcomeric proteins, but a significant proportion of patients lack a genetic diagnosis. We …

Cardiac troponin C (cTnC) is the regulatory protein that initiates cardiac contraction in
response to Ca 2+. TnC binding Ca 2+ initiates a cascade of protein–protein interactions …

One of the complexities of understanding the pathology of familial forms of cardiac diseases
is the level of mutation incorporation in sarcomeres. Computational models of the sarcomere …