In the right place at the right time: visualizing and understanding mRNA localization

AR Buxbaum, G Haimovich, RH Singer - Nature reviews Molecular cell …, 2015 - nature.com
The spatial regulation of protein translation is an efficient way to create functional and
structural asymmetries in cells. Recent research has furthered our understanding of how …

RNA trafficking and subcellular localization—a review of mechanisms, experimental and predictive methodologies

J Wang, M Horlacher, L Cheng… - Briefings in …, 2023 - academic.oup.com
RNA localization is essential for regulating spatial translation, where RNAs are trafficked to
their target locations via various biological mechanisms. In this review, we discuss RNA …

[HTML][HTML] eRNAs are required for p53-dependent enhancer activity and gene transcription

CA Melo, J Drost, PJ Wijchers, H van de Werken… - Molecular cell, 2013 - cell.com
Binding within or nearby target genes involved in cell proliferation and survival enables the
p53 tumor suppressor gene to regulate their transcription and cell-cycle progression. Using …

The synthetic biology toolbox for tuning gene expression in yeast

H Redden, N Morse, HS Alper - FEMS yeast research, 2015 - search.proquest.com
Saccharomyces cerevisiae can serve as a key production platform for biofuels,
nutraceuticals, industrial compounds, and therapeutic proteins. Over the recent years …

[HTML][HTML] Protein targeting to subcellular organelles via MRNA localization

BL Weis, E Schleiff, W Zerges - … et Biophysica Acta (BBA)-Molecular Cell …, 2013 - Elsevier
Cells have complex membranous organelles for the compartmentalization and regulation of
most intracellular processes. Organelle biogenesis and maintenance requires newly …

Selective fluorescent detection of RNA in living cells by using imidazolium-based cyclophane

B Shirinfar, N Ahmed, YS Park, GS Cho… - Journal of the …, 2013 - ACS Publications
A water-soluble imidazolium-based fluorescent chemosensor senses RNA selectively
through fluorescence enhancement over other biologically relevant biomolecules in …

Applications of computational modeling in metabolic engineering of yeast

EJ Kerkhoven, PJ Lahtvee, J Nielsen - FEMS yeast research, 2015 - academic.oup.com
Synthetic biology and metabolic engineering enable generation of novel cell factories that
efficiently convert renewable feedstocks into biofuels, bulk, and fine chemicals, thus creating …

The many functions of mRNA localization during normal development and disease: from pillar to post

NAL Cody, C Iampietro… - Wiley Interdisciplinary …, 2013 - Wiley Online Library
The regulated intracellular trafficking and localized translation of mRNA molecules
represents an important and prevalent mechanism of gene regulation. This process plays a …

Core Fermentation (CoFe) granules focus coordinated glycolytic mRNA localization and translation to fuel glucose fermentation

F Morales-Polanco, C Bates, J Lui, J Casson, CA Solari… - IScience, 2021 - cell.com
Glycolysis is a fundamental metabolic pathway for glucose catabolism across biology, and
glycolytic enzymes are among the most abundant proteins in cells. Their expression at such …

Live-cell imaging of Pol II promoter activity to monitor gene expression with RNA IMAGEtag reporters

I Shin, J Ray, V Gupta, M Ilgu, J Beasley… - Nucleic acids …, 2014 - academic.oup.com
We describe a ribonucleic acid (RNA) reporter system for live-cell imaging of gene
expression to detect changes in polymerase II activity on individual promoters in individual …