Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer

J Fernandez-Mateos, GD Cresswell, N Trahearn… - Nature Cancer, 2024 - nature.com
Cancer evolution lays the groundwork for predictive oncology. Testing evolutionary metrics
requires quantitative measurements in controlled clinical trials. We mapped genomic …

Novel multiparametric magnetic resonance imaging-based deep learning and clinical parameter integration for the prediction of long-term biochemical recurrence-free …

HW Lee, E Kim, I Na, CK Kim, SI Seo, H Park - Cancers, 2023 - mdpi.com
Simple Summary Existing research on predicting biochemical recurrence after prostate
surgery has been insufficient. Here, we aimed to predict biochemical recurrence after radical …

Models predicting survival to guide treatment decision-making in newly diagnosed primary non-metastatic prostate cancer: a systematic review

D Thurtle, SH Rossi, B Berry, P Pharoah… - BMJ open, 2019 - bmjopen.bmj.com
Objectives Men diagnosed with non-metastatic prostate cancer require standardised and
robust long-term prognostic information to help them decide on management. Most currently …

Prostate cancer screening: Continued controversies and novel biomarker advancements

A Tidd-Johnson, SA Sebastian, M Afaq… - Current …, 2022 - journals.lww.com
Prostate cancer (PCa) screening remains one of the most controversial topics in clinical and
public health. Despite being the second most common cancer in men worldwide …

A novel predictor tool of biochemical recurrence after radical prostatectomy based on a five-microRNA tissue signature

Z Zhao, S Weickmann, M Jung, M Lein, E Kilic… - Cancers, 2019 - mdpi.com
Within five to ten years after radical prostatectomy (RP), approximately 15–34% of prostate
cancer (PCa) patients experience biochemical recurrence (BCR), which is defined as …

Circular RNAs and their linear transcripts as diagnostic and prognostic tissue biomarkers in prostate cancer after prostatectomy in combination with clinicopathological …

H Rochow, M Jung, S Weickmann, B Ralla… - International Journal of …, 2020 - mdpi.com
As new biomarkers, circular RNAs (circRNAs) have been largely unexplored in prostate
cancer (PCa). Using an integrative approach, we aimed to evaluate the potential of …

Urinary oestrogen steroidome as an indicator of the risk of localised prostate cancer progression

JP Emond, L Lacombe, P Caron, V Turcotte… - British Journal of …, 2021 - nature.com
Abstract Background Prostate cancer (PCa) is the most common cancer in North American
men. Beyond the established contribution of androgens to disease progression, growing …

[HTML][HTML] A new risk stratification system of prostate cancer to identify high-risk biochemical recurrence patients

X Wu, D Lv, M Eftekhar, A Khan, C Cai… - Translational …, 2020 - ncbi.nlm.nih.gov
Background Biochemical recurrence (BCR) is considered a decisive risk factor for clinical
recurrence and the metastasis of prostate cancer (PCa). Therefore, we developed and …

[HTML][HTML] Methylation markers in prostate biopsies are prognosticators for late biochemical recurrence and therapy after surgery in prostate cancer patients

AJ Savio, S Kamdar, R Jeyapala… - The Journal of Molecular …, 2020 - Elsevier
After diagnosis of prostate cancer is confirmed by a positive biopsy, the tumor may be
surgically removed via radical prostatectomy (RP). However, many prostate cancer patients …

Differential outcomes of re-stratified high-risk prostate cancer patients treated with external beam radiation therapy plus high-dose-rate brachytherapy boost

D Carignan, B Morales, P Després, W Foster… - Journal of …, 2024 - termedia.pl
Purpose: We report outcomes of high-risk prostate cancer (PCa) patients, initially classified
according to a 3-tier NCCN classification system, treated with external beam radiation …