Research on cognitive control and executive function has long recognized the relevance of
motivational factors. Recently, however, the topic has come increasingly to center stage, with …

Brains systems undergo unique and specific dynamic changes at the cellular, circuit, and
systems level that underlie the transition to adult-level cognitive control. We integrate …

The effective mimicry of neurons is key to the development of neuromorphic electronics.
However, artificial neurons are not typically capable of operating in biological environments …

The major mechanism for generating diversity of neuronal connections beyond their genetic
determination is the activity-dependent stabilization and selective elimination of the initially …

Recent years have seen a rejuvenation of interest in studies of motivation–cognition
interactions arising from many different areas of psychology and neuroscience. The present …

Among the many neuromodulators used by the mammalian brain to regulate circuit function
and plasticity, dopamine (DA) stands out as one of the most behaviorally powerful …

This review describes unique neuromodulatory influences on working memory prefrontal
cortical (PFC) circuits that coordinate cognitive strength with arousal state. Working memory …

Mesocotical dopamine (DA) inputs to the prefrontal cortex (PFC) play a crtical role in normal
cognitive process and neuropsychiatic pathologies. This DA input regulates aspects of …

Abstract Dopamine (DA) D1 receptor (D1R) stimulation in prefrontal cortex (PFC) produces
an'inverted-U'dose-response, whereby either too little or too much D1R stimulation impairs …

Rett Syndrome (RTT) is a devastating neurological disorder that is caused by mutations in
the MECP2 gene. Mecp2-mutant mice have been used as a model system to study the …