Enzymes of the mevalonate pathway of isoprenoid biosynthesis

HM Miziorko - Archives of biochemistry and biophysics, 2011 - Elsevier
The mevalonate pathway accounts for conversion of acetyl-CoA to isopentenyl 5-
diphosphate, the versatile precursor of polyisoprenoid metabolites and natural products. The …

A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?

A Hemmerlin, JL Harwood, TJ Bach - Progress in lipid research, 2012 - Elsevier
When compared to other organisms, plants are atypical with respect to isoprenoid
biosynthesis: they utilize two distinct and separately compartmentalized pathways to build …

Genes, enzymes and chemicals of terpenoid diversity in the constitutive and induced defence of conifers against insects and pathogens

CI Keeling, J Bohlmann - New Phytologist, 2006 - Wiley Online Library
Insects select their hosts, but trees cannot select which herbivores will feed upon them.
Thus, as long‐lived stationary organisms, conifers must resist the onslaught of varying and …

Deoxyxylulose phosphate pathway to terpenoids

W Eisenreich, F Rohdich, A Bacher - Trends in plant science, 2001 - cell.com
Recently, a mevalonate-independent pathway was discovered in bacteria and plants that
leads to the formation of isopentenyl diphosphate and dimethylallyl diphosphate, the two …

The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases

JA Friesen, VW Rodwell - Genome biology, 2004 - Springer
Summary The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
catalyzes the conversion of HMG-CoA to mevalonate, a four-electron oxidoreduction that is …

Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells

A Hemmerlin, JF Hoeffler, O Meyer, D Tritsch… - Journal of Biological …, 2003 - ASBMB
In plants, two pathways are utilized for the synthesis of isopentenyl diphosphate, the
universal precursor for isoprenoid biosynthesis. The key enzyme of the cytoplasmic …

The carotenoid pigment zeaxanthin—a review

MG Sajilata, RS Singhal… - Comprehensive reviews in …, 2008 - Wiley Online Library
Scientific evidence linking several diseases with diet has brought to light the beneficial
effects of a number of natural food ingredients. Zeaxanthin is one such natural pigment …

Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein

F Rohdich, S Hecht, K Gärtner… - Proceedings of the …, 2002 - National Acad Sciences
Isopentenyl diphosphate and dimethylallyl diphosphate serve as the universal precursors for
the biosynthesis of terpenes. Although their biosynthesis by means of mevalonate has been …

Towards efficient terpenoid biosynthesis: manipulating IPP and DMAPP supply

Q Wang, S Quan, H Xiao - Bioresources and Bioprocessing, 2019 - Springer
Terpenoids are a group of largest natural products with important biological functions, and
their efficient biosynthesis is of particular importance to both academia and industry. As the …

Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-d-erythritol

H Lüttgen, F Rohdich, S Herz… - Proceedings of the …, 2000 - National Acad Sciences
A comparative analysis of all published complete genomes indicated that the putative
orthologs of the unannotated ychB gene of Escherichia coli follow the distribution of the dxs …