Being deeply connected to signalling, cell dynamics, growth, regulation, and defence,
endocytic processes are linked to almost all aspects of cell life and disease. In this review …

All cells undergo rapid remodeling of their actin networks to regulate such critical processes
as endocytosis, cytokinesis, cell polarity, and cell morphogenesis. These events are driven …

Autophagy is primarily considered a non‐selective degradation process induced by
starvation. Nutrient‐independent basal autophagy, in contrast, imposes intracellular QC by …

Although fusion mechanisms are highly conserved in evolution and among organelles of the
exocytic and endocytic pathways, yeast vacuole homotypic fusion offers unique technical …

It is now well appreciated that derivatives of phosphatidylinositol (PtdIns) are key regulators
of many cellular processes in eukaryotes. Of particular interest are phosphoinositides (mono …

Endocytosis describes the processes by which proteins, peptides and solutes, and also
pathogens, enter the cell. Endocytosed material progresses to endosomes. Genetic studies …

Niemann-Pick type C is a storage disease caused by dysfunction of NPC proteins, which
transport cholesterol from the lumen of lysosomes to the limiting membrane of that …

The accumulation of damaged and aggregated proteins is a hallmark of aging and
increased proteotoxic stress. To limit the toxicity of damaged and aggregated proteins and to …

Abstract ACTIN-RELATED PROTEINS 2 and 3 form the major subunits of the ARP2/3
complex, which is known as an important regulator of actin organization in diverse …

Actin and its associated proteins participate in several intracellular trafficking mechanisms.
This review assesses recent work that shows how actin participates in the terminal trafficking …