The ring-like cohesin complex mediates sister-chromatid cohesion by encircling pairs of
sister chromatids. Cohesin also extrudes loops along chromatids. Whether the two activities …

Neutrophils are innate immune cells that are key to protecting the host against infection and
maintaining body homeostasis. However, if dysregulated, they can contribute to disease …

Background B-type lamins are critical nuclear envelope proteins that interact with the three-
dimensional genomic architecture. However, identifying the direct roles of B-lamins on …

The spatial segregation of the genome into compartments is a major feature of 3D genome
organization. New data on mammalian chromosome organization across different conditions …

To spread from a localized tumor, metastatic cancer cells must squeeze through
constrictions that cause major nuclear deformations. Since chromosome structure affects …

Chromatin architecture regulates gene expression and shapes cellular identity, particularly
in neuronal cells. Specifically, polycomb group (PcG) proteins enable establishment and …

Mechanical extracellular signals elicit chromatin remodeling via the mechanotransduction
pathway, thus determining cellular function. However, the reverse pathway is an open …

ABSTRACT BACKGROUND B-type lamins are critical nuclear envelope proteins that
interact with the 3D genomic architecture. However, identifying the direct roles of B-lamins …

Structural biology has traditionally focused on the structures of proteins, short nucleic acids,
small molecules, and their complexes. However, it is now widely recognized that the 3D …

Nuclear actin polymerization helps facilitate chromosome compartment switches that can
shift damaged DNA toward a nuclear environment that is favorable for DNA repair. Yet …