[HTML][HTML] Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models
S Caddeo, M Boffito, S Sartori - Frontiers in bioengineering and …, 2017 - frontiersin.org
In the tissue engineering (TE) paradigm, engineering and life sciences tools are combined
to develop bioartificial substitutes for organs and tissues, which can in turn be applied in …
to develop bioartificial substitutes for organs and tissues, which can in turn be applied in …
Organotypic and microphysiological human tissue models for drug discovery and development—current state-of-the-art and future perspectives
The number of successful drug development projects has been stagnant for decades
despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …
despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …
Cardiac microphysiological devices with flexible thin-film sensors for higher-throughput drug screening
Microphysiological systems and organs-on-chips promise to accelerate biomedical and
pharmaceutical research by providing accurate in vitro replicas of human tissue. Aside from …
pharmaceutical research by providing accurate in vitro replicas of human tissue. Aside from …
[HTML][HTML] Spatiotemporal cell junction assembly in human iPSC-CM models of arrhythmogenic cardiomyopathy
Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder that causes life-
threatening arrhythmias and myocardial dysfunction. Pathogenic variants in Plakophilin-2 …
threatening arrhythmias and myocardial dysfunction. Pathogenic variants in Plakophilin-2 …
[HTML][HTML] Two-dimensional TIRF-SIM–traction force microscopy (2D TIRF-SIM-TFM)
Quantifying small, rapidly evolving forces generated by cells is a major challenge for the
understanding of biomechanics and mechanobiology in health and disease. Traction force …
understanding of biomechanics and mechanobiology in health and disease. Traction force …
Contractility and calcium transient maturation in the human iPSC-derived cardiac microfibers
D Strimaityte, C Tu, A Yanez, I Itzhaki… - … applied materials & …, 2022 - ACS Publications
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are considered
immature in the sarcomere organization, contractile machinery, calcium transient, and …
immature in the sarcomere organization, contractile machinery, calcium transient, and …
[HTML][HTML] Human iPSC-derived myocardium-on-chip with capillary-like flow for personalized medicine
The heart wall tissue, or the myocardium, is one of the main targets in cardiovascular
disease prevention and treatment. Animal models have not been sufficient in mimicking the …
disease prevention and treatment. Animal models have not been sufficient in mimicking the …
Human heart anoxia and reperfusion tissue (HEART) model for the rapid study of exosome bound miRNA expression as biomarkers for myocardial infarction
Current biomarkers for myocardial infarction (MI) diagnosis are typically late markers
released upon cell death, incapable of distinguishing between ischemic and reperfusion …
released upon cell death, incapable of distinguishing between ischemic and reperfusion …
[HTML][HTML] Traction force microscopy of engineered cardiac tissues
Cardiac tissue development and pathology have been shown to depend sensitively on
microenvironmental mechanical factors, such as extracellular matrix stiffness, in both in vivo …
microenvironmental mechanical factors, such as extracellular matrix stiffness, in both in vivo …
[HTML][HTML] Engineering the maturation of stem cell-derived cardiomyocytes
The maturation of human stem cell-derived cardiomyocytes (hSC-CMs) has been a major
challenge to further expand the scope of their application. Over the past years, several …
challenge to further expand the scope of their application. Over the past years, several …