BACKGROUND Although laboratory procedures, along with culture media formulations,
have improved over the past two decades, the issue remains that human IVF is performed in …

With the worldwide move towards single embryo transfer there has been a renewed focus
on the requirement for reliable means of assessing embryo viability. In an era of …

Reproductive aging in female mammals is an irreversible process associated with declining
oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of …

In brief Reactive oxygen species are generated throughout the pre-implantation period and
are necessary for normal embryo formation. However, at pathological levels, they result in …

In human in-vitro fertilization (IVF) embryos are routinely transferred to the uterus on day 2 or
day 3 of development. Resultant implantation and pregnancy rates are disappointingly low …

The effectiveness of blastocyst culture and transfer in human in-vitro fertilization (IVF) was
evaluated in a prospective randomized trial in patients having a moderate to good response …

Epidemiological studies have indicated that susceptibility of human adults to hypertension
and cardiovascular disease may result from intrauterine growth restriction and low birth …

BACKGROUND The advances in the world of IVF during the last decades have been rapid
and impressive and culture media play a major role in this success. Until the 1980s fertility …

Objective: To determine whether the transfer of blastocysts on day 5, developed in
sequential culture media, resulted in an increase in implantation rate compared with …

This review uses nutritional markers of normal and impaired development to address the
question; what makes a viable mammalian preimplantation embryo? Resolution of this …