Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …

Diabetes mellitus is one of the major public health problems worldwide. Considerable recent
evidence suggests that the cellular reduction-oxidation (redox) imbalance leads to oxidative …

Abstract Silent information regulator 1 (SIRT1) is a ubiquitously expressed protein and has
an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a …

Significance: Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a
disease that currently affects∼ 8% of the adult population worldwide. Pancreatic beta-cell …

Obesity, especially of the abdominal type, is a health problem that constitutes metabolic
syndrome and increases the incidence of various diseases, including diabetes …

Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …

Sirtuin 1 (SIRT1) regulates inflammation, aging (life span and health span), calorie
restriction/energetics, mitochondrial biogenesis, stress resistance, cellular senescence …

Pancreatic β-cell failure is a critical event in the onset of both main types of diabetes mellitus
but underlying mechanisms are not fully understood. β-cells have low anti-oxidant capacity …

The endoplasmic reticulum (ER) is a well-orchestrated protein-folding machine composed of
protein chaperones, proteins that catalyze protein folding, and sensors that detect the …

Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and
its hallmarks are pancreatic β‐cell dysfunction and insulin resistance. Under diabetic …