Abstract Turnbull, Andrew V., and Catherine L. Rivier. Regulation of the Hypothalamic-
Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action. Physiol. Rev. 79: 1 …

In the research field of psychoneuroimmunology, accumulating evidence has indicated the
existence of reciprocal communication pathways between nervous, endocrine and immune …

I. Introduction THE existence of mechanisms that provide immunity to an infective agent was
inferred from empirical observations obtained through the ingenuity and deductive capacity …

Compelling data has been amassed indicating that soluble factors, or cytokines, emanating
from the immune system can have profound effects on the neuroendocrine system, in …

High levels of immunoreactive cyclooxygenase (Cox; prostaglandin H synthase) are present
in synovia from patients with rheumatoid arthritis (RA). We now show that the recently …

Endotoxin is considered to be a systemic (immunological) stressor eliciting a prolonged
activation of the hypothalamo-pituitary-adrenal (HPA) axis. The HPA-axis response after an …

Abstract The cytokine interleukin-6 (IL-6) is an important mediator of inflammatory and
immune responses in the periphery. IL-6 is produced in the periphery and acts systemically …

Abstract Systemic interleukin‐1 (IL‐1) activates the hypothalamo‐pituitary‐adrenal (HPA)
axis, an effect exerted through increased synthesis and secretion of corticotropin‐releasing …

There are exciting new developments regarding the molecular mechanisms involved in the
influence of circulating proinflammatory molecules within cells of the blood‐brain barrier …

The distribution of interleukin 6 (IL‐6) mRNA and IL‐6 receptor (IL‐6R) mRNA in the brain of
adult male rats was studied at the light microscope level by in situ hybridization …