Cellular senescence is a ubiquitous process with roles in tissue remodelling, including
wound repair and embryogenesis. However, prolonged senescence can be maladaptive …

Mammalian sirtuins have emerged in recent years as critical modulators of multiple
biological processes, regulating cellular metabolism, DNA repair, gene expression, and …

SIRT6, a member of the Sirtuin family of NAD+-dependent enzymes, has established roles in
chromatin signaling and genome maintenance. Through these functions, SIRT6 protects …

Mesenchymal stem cells (MSCs) are characterized to have the capacity of self-renewal and
the potential to differentiate into mesoderm, ectoderm-like and endoderm-like cells. MSCs …

Aging impairs the functions of human mesenchymal stem cells (MSCs), thereby severely
reducing their beneficial effects on myocardial infarction (MI). MicroRNAs (miRNAs) play …

The beneficial functions of mesenchymal stem cells (MSCs) decline with age, limiting their
therapeutic efficacy for myocardial infarction (MI). Macrophage migration inhibitory factor …

Apelin, an endogenous ligand for the G protein-coupled receptor APJ, is widely expressed
in various organs. Recent research has indicated that the Apelin/APJ system plays an …

Advanced age is a shared risk factor for many chronic and debilitating skeletal diseases
including osteoporosis and periodontitis. Mesenchymal stem cells develop various aging …

Osteoarthritis (OA) is a chronic joint disease characterized by articular cartilage
degeneration, secondary bone hyperplasia, inadequate extracellular matrix synthesis and …

In mammalian cells, there are seven members of the sirtuin protein family (SIRT1–7). SIRT1,
SIRT6, and SIRT7 catalyze posttranslational modification of proteins in the nucleus, SIRT3 …