One of the most important metabolic hallmarks of cancer cells is deregulation of lipid
metabolism. In addition, enhancing de novo fatty acid (FA) synthesis, increasing lipid uptake …

The Warburg effect describes the phenomenon by which cancer cells obtain energy from
glycolysis even under normoxic (O2-sufficient) conditions. Tumor tissues are generally …

The development of cancer involves mechanisms by which aberrant cells overcome normal
regulatory pathways that limit their numbers and their migration. The evasion of programmed …

Low-density lipoprotein receptor–related protein-1 (LRP1) is an endocytic receptor for
numerous proteins that are both structurally and functionally diverse. In some cell types …

Objective—Patients with cancer are at an increased risk for venous thromboembolism (VTE).
Clotting factor VIII activity (FVIII) has been established as risk factor of primary and recurrent …

The shed form of LRP1/CD91, which is generated at increased levels in inflammation,
regulates cell-signaling and cytokine expression by macrophages. LRP1 is a type-1 …

Background Extracellular Hsp90 protein (eHsp90) potentiates cancer cell motility and
invasion through a poorly understood mechanism involving ligand mediated function with its …

Through their ability to degrade the extracellular matrix, proteases mediate cancer cell
invasion and metastasis. Paradoxically, some serine protease inhibitors (serpins) are often …

Recent advances in immunology and cancer research show that fatty acids, their
metabolism and their sensing have a crucial role in the biology of many different cell types …

Target-specific treatment modalities are currently not available for triple-negative breast
cancer (TNBC), and acquired chemotherapy resistance is a primary obstacle for the …