Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …

Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

In the past decade, substantial advances have been made in understanding the biology of
tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A …

Tumor-infiltrating myeloid cells (TIMs) are crucial cell populations involved in tumor immune
escape, and their functions are regulated by multiple epigenetic mechanisms. The precise …

Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration
correlates with lower patient survival and resistance to therapy. Tumor-associated …

Single-cell technologies have revealed the complexity of the tumour immune
microenvironment with unparalleled resolution,,,,,,,–. Most clinical strategies rely on …

The liver is the sixth most common site of primary cancer in humans and the fourth leading
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …

Microglia are emerging as critical regulators of neuronal function and behavior in nearly
every area of neuroscience. Initial reports focused on classical immune functions of …