Lipid compartments and lipid metabolism as therapeutic targets against coronavirus
D Cesar-Silva, FS Pereira-Dutra, ALM Giannini… - Frontiers in …, 2023 - frontiersin.org
Lipids perform a series of cellular functions, establishing cell and organelles' boundaries,
organizing signaling platforms, and creating compartments where specific reactions occur …
organizing signaling platforms, and creating compartments where specific reactions occur …
Role of cytochrome P450 2C9 in COVID-19 treatment: current status and future directions
The major human liver drug metabolising cytochrome P450 (CYP) enzymes are
downregulated during inflammation and infectious disease state, especially during …
downregulated during inflammation and infectious disease state, especially during …
Association of fluvoxamine with mortality and symptom resolution among inpatients with COVID-19 in Uganda: a prospective interventional open-label cohort study
BJ Kirenga, L Mugenyi, M Sánchez-Rico, H Kyobe… - Molecular …, 2023 - nature.com
Prior research suggests that fluvoxamine, a selective serotonin reuptake inhibitor (SSRI)
used for the treatment of obsessive-compulsive disorder and major depressive disorder …
used for the treatment of obsessive-compulsive disorder and major depressive disorder …
Association of severe mental illness and septic shock case fatality rate in patients admitted to the intensive care unit: A national population-based cohort study
Background Patients with severe mental illness (SMI)(ie, schizophrenia, bipolar disorder, or
major depressive disorder) have been reported to have excess mortality rates from infection …
major depressive disorder) have been reported to have excess mortality rates from infection …
Medications modulating the acid sphingomyelinase/ceramide system and 28-day mortality among patients with SARS-CoV-2: an observational study
Prior evidence indicates the potential central role of the acid sphingomyelinase
(ASM)/ceramide system in the infection of cells with SARS-CoV-2. We conducted a …
(ASM)/ceramide system in the infection of cells with SARS-CoV-2. We conducted a …
Genetic analyses point to alterations in immune-related pathways underpinning the association between psychiatric disorders and COVID-19
A Monistrol-Mula, S Diaz-Torres… - Molecular …, 2024 - nature.com
Current literature suggests that people with psychiatric disorders have a higher risk of
COVID-19 infection and a worse prognosis of the disease. We aimed to study the genetic …
COVID-19 infection and a worse prognosis of the disease. We aimed to study the genetic …
Early fluvoxamine reduces the risk for clinical deterioration in symptomatic outpatients with Covid-19: a real-world, retrospective, before–after analysis
Fluvoxamine, a selective serotonin reuptake inhibitor with anti-inflammatory properties, has
gained attention as a repurposed drug to treat COVID-19. We aimed to explore the potential …
gained attention as a repurposed drug to treat COVID-19. We aimed to explore the potential …
The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection
SARS-CoV-2 infection can cause severe pneumonia, wherein exacerbated inflammation
plays a major role. This is reminiscent of the process commonly termed cytokine storm, a …
plays a major role. This is reminiscent of the process commonly termed cytokine storm, a …
Relationship between antidepressants and severity of SARS-CoV-2 Omicron infection: A retrospective cohort study using real-world data
H Wang, Y Wei, CT Hung, X Jiang, C Li… - The Lancet Regional …, 2023 - thelancet.com
Background Few studies have used real-world data to evaluate the impact of antidepressant
use on the risk of developing severe outcomes after SARS-CoV-2 Omicron infection …
use on the risk of developing severe outcomes after SARS-CoV-2 Omicron infection …
Antipsychotic use and 28-day mortality in patients hospitalized with COVID-19: A multicenter observational retrospective study
M Sánchez-Rico, A Edán-Sánchez, M Olfson… - European …, 2023 - Elsevier
Prior research has yielded conflicting results about the potential influence of antipsychotics
in patients with COVID-19. In this multicenter retrospective study, we examined the …
in patients with COVID-19. In this multicenter retrospective study, we examined the …