Folate being an important vitamin of B Complex group in our diet plays an important role not
only in the synthesis of DNA but also in the maintenance of methylation reactions in the …

There are numerous theories of aging, a process which still seems inevitable. Aging leads to
cancer and multi-systemic disorders as well as chronic diseases. Decline in age-associated …

Epidemiologic and mechanistic evidence suggests that folate is involved in colorectal
neoplasia. Some polymorphic genes involved in folate metabolism …

During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …

Advances in molecular biology greatly contributed, in the past decades, to a deeper
understanding of the role of gene function in disease development. Environmental as well …

Impaired folate-mediated 1-carbon metabolism has been linked to multiple disease
outcomes. A better understanding of the nutritional and genetic influences on this complex …

Mutations in the MTR gene, which encodes methionine synthase on human chromosome
1p43, result in the methylcobalamin deficiency G (cblG) disorder, which is characterized by …

Background: We investigated whether chromosome 9p21. 3 single-nucleotide
polymorphisms (SNPs), identified in coronary heart disease (CHD) genome-wide …

We have estimated the risk of coronary heart disease (CHD) from family history of CHD
(FHCHD) in 2827 healthy European middle‐aged men, and explored the extent to which this …

Alzheimer's disease (AD) is the major cause of dementia and no preventive or effective
treatment has been established to date. The etiology of AD is poorly understood, but genetic …