Reciprocal interactions between epithelial and mesenchymal tissues play a fundamental
role in the morphogenesis of teeth and regulate all aspects of tooth development. Extensive …

Renal cell carcinoma (RCC) accounts for 90% of all kidney cancers. Due to poor diagnosis,
high resistance to the systemic therapies and the fact that most RCC cases occur …

Genome-wide association studies (GWAS) have identified hundreds of genetic risk regions
for kidney dysfunction [estimated glomerular filtration rate (eGFR)]; however, the causal …

Wnt-stimulated β-catenin transcriptional regulation is necessary for the development of most
organs, including teeth. Bcl9 and Bcl9l are tissue-specific transcriptional cofactors that …

Background MicroRNAs (miRNAs) play a key role in regulating cell differentiation. In the
present study, we aimed to explore the role of miR-140-5p in odontoblastic differentiation of …

To explore the effects and mechanisms of paracrine factors secreted from human adipose
mesenchymal stem cell (hAdMSCs) that are activated by hypoxia on radioprotection against …

A new field of dental medicine seeks to exploit nature's solution for repairing damaged
tissues, through the process of regeneration. Most adult mammalian tissues have limited …

In adult tissues and organs with high turnover rates, the generation of transit-amplifying cell
(TAC) populations from self-renewing stem cells drives cell replacement. The role of stem …

In mice, the incisors grow throughout the animal's life, and this continuous renewal is driven
by dental epithelial and mesenchymal stem cells. Sox2 is a principal marker of the epithelial …

Bone morphogenetic protein (BMP) signaling performs multiple essential functions during
craniofacial development. In this study, we used the adult mouse incisor as a model to …