Myofibres serve as the functional unit for locomotion, with the sarcomere as fundamental
subunit. Running the entire length of this structure are hundreds of myonuclei, located at the …

Proprioception is sensed by muscle spindles for precise locomotion and body posture.
Unlike the neuromuscular junction (NMJ) for muscle contraction which has been well …

Background Intervertebral disc degeneration (IVDD) is a leading cause of low back pain
(LBP). The pathological process of IVDD is associated with inflammatory reactions and …

The mechanism of action of low-density lipoprotein receptor related protein 4 (LRP4) is
mediated largely via the Agrin-LRP4-MuSK signalling pathway in the nervous system. LRP4 …

Abstract Background Neuromuscular junctions (NMJs) are peripheral synapses connecting
motoneurons and skeletal myofibers. At the postsynaptic side in myofibers, acetylcholine …

Background Dendritic spines are the sites of excitatory synapses on pyramidal neurons, and
their development is crucial for neural circuits and brain functions. The spine shape, size, or …

Aging plays an essential role in the development for chronic obstructive pulmonary disease
(COPD). The aim of this study was to identify and validate the potential aging-related genes …

A central event in the pathogenesis of motor neuron disease (MND) is the loss of
neuromuscular junctions (NMJs), yet the mechanisms that lead to this event in MND remain …

The vertebrate neuromuscular junction (NMJ) is formed by a presynaptic motor nerve
terminal and a postsynaptic muscle specialization. Cumulative evidence reveals that Wnt …

During early forebrain development, the establishment of the regional identity of neural
progenitor cells (NPCs) relies on the integration of signals from multiple signaling centers …