The risks of miRNA therapeutics: in a drug target perspective
S Zhang, Z Cheng, Y Wang, T Han - Drug design, development …, 2021 - Taylor & Francis
RNAi therapeutics have been growing. Patisiran and givosiran, two siRNA-based drugs,
were approved by the Food and Drug Administration in 2018 and 2019, respectively …
were approved by the Food and Drug Administration in 2018 and 2019, respectively …
MicroRNAs in gynecological cancers: Small molecules with big implications
Gynecological cancers (GCs) are often diagnosed at advanced stages, limiting the efficacy
of available therapeutic options. Thus, there remains an urgent and unmet need for …
of available therapeutic options. Thus, there remains an urgent and unmet need for …
[HTML][HTML] Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages
X Ying, Q Wu, X Wu, Q Zhu, X Wang, L Jiang, X Chen… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Cancer secreted exosomal miRNAs are emerging as mediators between tumor-stoma
crosstalk. Here, we show epithelial ovarian cancer (EOC)-derived exosomes activated …
crosstalk. Here, we show epithelial ovarian cancer (EOC)-derived exosomes activated …
Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway
Y Li, W Sun, N Han, Y Zou, D Yin - BMC cancer, 2018 - Springer
Background Curcumin, a primary active ingredient extracted from the Curcuma longa, has
been recently identified as a potential anti-tumor agent in multiple kinds of cancers …
been recently identified as a potential anti-tumor agent in multiple kinds of cancers …
Role of miR‐221/222 in tumor development and the underlying mechanism
Q Song, Q An, B Niu, X Lu, N Zhang… - Journal of Oncology, 2019 - Wiley Online Library
MicroRNA‐221/222 (miRNA‐221/222, miR‐221/222) is a noncoding microRNA which is
widely distributed in eukaryotic organisms and deeply involved in the posttranscriptional …
widely distributed in eukaryotic organisms and deeply involved in the posttranscriptional …
Naturally existing isoforms of miR-222 have distinct functions
F Yu, KA Pillman, CT Neilsen, J Toubia… - Nucleic acids …, 2017 - academic.oup.com
Deep-sequencing reveals extensive variation in the sequence of endogenously expressed
microRNAs (termed 'isomiRs') in human cell lines and tissues, especially in relation to the …
microRNAs (termed 'isomiRs') in human cell lines and tissues, especially in relation to the …
MicroRNA-222 reprogrammed cancer-associated fibroblasts enhance growth and metastasis of breast cancer
Abstract Background Cancer-associated fibroblasts (CAFs) are known to impact on tumour
behaviour, but the mechanisms controlling this are poorly understood. Methods Breast …
behaviour, but the mechanisms controlling this are poorly understood. Methods Breast …
Panax notoginseng saponins attenuate lung cancer growth in part through modulating the level of Met/miR-222 axis
Q Yang, P Wang, J Cui, W Wang, Y Chen… - Journal of …, 2016 - Elsevier
Ethnopharmacological relevance Panax notoginseng saponins (PNS) are the major
chemical constituents of Panax notoginseng (Burkill) FH Chen (Araliaceae), a medicinal …
chemical constituents of Panax notoginseng (Burkill) FH Chen (Araliaceae), a medicinal …
[HTML][HTML] MiR-222 overexpression promotes proliferation of human hepatocellular carcinoma HepG2 cells by downregulating p27
YF Yang, F Wang, JJ Xiao, Y Song… - … journal of clinical and …, 2014 - ncbi.nlm.nih.gov
Objective: Hepatocellular carcinoma (HCC) represents the third leading cause of cancer-
related death worldwide. Increasing evidence suggests that microRNAs, a novel class of …
related death worldwide. Increasing evidence suggests that microRNAs, a novel class of …
Upregulation of the long non‐coding RNA FALEC promotes proliferation and migration of prostate cancer cell lines and predicts prognosis of PCa patients
R Zhao, F Sun, X Bei, X Wang, Y Zhu, C Jiang… - The …, 2017 - Wiley Online Library
Background LncRNAs are aberrantly expressed in various cancer types and were found to
be a responsible prognosis biomarker and therapeutic target of many human cancers …
be a responsible prognosis biomarker and therapeutic target of many human cancers …