RNAi therapeutics have been growing. Patisiran and givosiran, two siRNA-based drugs,
were approved by the Food and Drug Administration in 2018 and 2019, respectively …

Gynecological cancers (GCs) are often diagnosed at advanced stages, limiting the efficacy
of available therapeutic options. Thus, there remains an urgent and unmet need for …

Cancer secreted exosomal miRNAs are emerging as mediators between tumor-stoma
crosstalk. Here, we show epithelial ovarian cancer (EOC)-derived exosomes activated …

Background Curcumin, a primary active ingredient extracted from the Curcuma longa, has
been recently identified as a potential anti-tumor agent in multiple kinds of cancers …

MicroRNA‐221/222 (miRNA‐221/222, miR‐221/222) is a noncoding microRNA which is
widely distributed in eukaryotic organisms and deeply involved in the posttranscriptional …

Deep-sequencing reveals extensive variation in the sequence of endogenously expressed
microRNAs (termed 'isomiRs') in human cell lines and tissues, especially in relation to the …

Abstract Background Cancer-associated fibroblasts (CAFs) are known to impact on tumour
behaviour, but the mechanisms controlling this are poorly understood. Methods Breast …

Ethnopharmacological relevance Panax notoginseng saponins (PNS) are the major
chemical constituents of Panax notoginseng (Burkill) FH Chen (Araliaceae), a medicinal …

Objective: Hepatocellular carcinoma (HCC) represents the third leading cause of cancer-
related death worldwide. Increasing evidence suggests that microRNAs, a novel class of …

Background LncRNAs are aberrantly expressed in various cancer types and were found to
be a responsible prognosis biomarker and therapeutic target of many human cancers …