Recent developments in age-related macular degeneration: a review

WM Al-Zamil, SA Yassin - Clinical interventions in aging, 2017 - Taylor & Francis
Background Visual impairment in elderly people is a considerable health problem that
significantly affects quality of life of millions worldwide. The magnitude of this issue is …

Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts

KM Gehrs, DH Anderson, LV Johnson… - Annals of …, 2006 - Taylor & Francis
Today, the average life expectancy in developed nations is over 80 years and climbing. And
yet, the quality of life during those additional years is often significantly diminished by the …

Complement factor H polymorphism in age-related macular degeneration

RJ Klein, C Zeiss, EY Chew, JY Tsai, RS Sackler… - Science, 2005 - science.org
Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. We
report a genome-wide screen of 96 cases and 50 controls for polymorphisms associated …

Complement factor H polymorphism and age-related macular degeneration

AO Edwards, R Ritter III, KJ Abel, A Manning… - Science, 2005 - science.org
Age-related macular degeneration (AMD) is a common, late-onset, and complex trait with
multiple risk factors. Concentrating on a region harboring a locus for AMD on 1q25-31, the …

[HTML][HTML] The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment

MJ Geerlings, EK de Jong, AI den Hollander - Molecular immunology, 2017 - Elsevier
Age-related macular degeneration (AMD) is a progressive retinal disease and the major
cause of irreversible vision loss in the elderly. Numerous studies have found both common …

Molecular pathology of age-related macular degeneration

X Ding, M Patel, CC Chan - Progress in retinal and eye research, 2009 - Elsevier
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the
world. Although the etiology and pathogenesis of AMD remain largely unclear, a complex …

Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor …

A Rivera, SA Fisher, LG Fritsche… - Human molecular …, 2005 - academic.oup.com
Age-related macular degeneration (AMD) is a multifactorial disease and a prevalent cause
of visual impairment in developed countries. Risk factors include environmental components …

The US twin study of age-related macular degeneration: relative roles of genetic and environmental influences

JM Seddon, J Cote, WF Page, SH Aggen… - Archives of …, 2005 - jamanetwork.com
Context Age-related macular degeneration (AMD) is the leading cause of irreversible
blindness among older individuals in many parts of the world. The relative importance of …

Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration

J Maller, S George, S Purcell, J Fagerness… - Nature …, 2006 - nature.com
Age-related macular degeneration (AMD) is a common, late-onset disease with seemingly
typical complexity: recurrence ratios for siblings of an affected individual are three-to sixfold …

The role of inflammation in the pathogenesis of age-related macular degeneration

LA Donoso, D Kim, A Frost, A Callahan… - Survey of …, 2006 - Elsevier
Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, is a
complex disease to study because of the potential role of demographic, environmental, and …