The proteasomal system
T Jung, B Catalgol, T Grune - Molecular aspects of medicine, 2009 - Elsevier
Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …
The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolism
Abstract Poly (ADP-ribose) polymerases (PARPs or ARTDs), originally described as DNA
repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and …
repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and …
Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early‐onset preeclampsia
Preeclampsia remains a leading cause of maternal and perinatal morbidity and mortality.
There have been no material advances in the treatment of preeclampsia for nearly 50 years …
There have been no material advances in the treatment of preeclampsia for nearly 50 years …
Serotonin 5-hydroxytryptamine2A receptor activation suppresses tumor necrosis factor-α-induced inflammation with extraordinary potency
B Yu, J Becnel, M Zerfaoui, R Rohatgi… - … of Pharmacology and …, 2008 - ASPET
The G protein-coupled serotonin 5-hydroxytryptamine (5-HT) 2A receptor is primarily
recognized for its role in brain neurotransmission, where it mediates a wide variety of …
recognized for its role in brain neurotransmission, where it mediates a wide variety of …
[HTML][HTML] Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer
Background Poly (ADP-ribose) polymerase (PARP) inhibitors (eg, olaparib) are effective
against BRCA-mutated cancers at/near maximum tolerated doses by trapping PARP-1 on …
against BRCA-mutated cancers at/near maximum tolerated doses by trapping PARP-1 on …
PRMT5 critically mediates TMAO-induced inflammatory response in vascular smooth muscle cells
A high plasma level of the choline-derived metabolite trimethylamine N-oxide (TMAO) is
closely related to the development of cardiovascular disease. However, the underlying …
closely related to the development of cardiovascular disease. However, the underlying …
Poly (ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-κB upon TLR4 stimulation
The role of NF-κB in the expression of inflammatory genes and its participation in the overall
inflammatory process of chronic diseases and acute tissue injury are well established. We …
inflammatory process of chronic diseases and acute tissue injury are well established. We …
Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes
A Agarwal, RZ Mahfouz, RK Sharma, O Sarkar… - Reproductive Biology …, 2009 - Springer
Maintaining the integrity of sperm DNA is vital to reproduction and male fertility. Sperm
contain a number of molecules and pathways for the repair of base excision, base …
contain a number of molecules and pathways for the repair of base excision, base …
The relation of markers of inflammation and endothelial dysfunction to the prevalence and progression of diabetic retinopathy: Wisconsin epidemiologic study of …
BEK Klein, MD Knudtson, MY Tsai… - Archives of …, 2009 - jamanetwork.com
Objective To determine the relation of glycemia, blood pressure, and serum total cholesterol
level as systemic markers of inflammation and endothelial dysfunction to the prevalence and …
level as systemic markers of inflammation and endothelial dysfunction to the prevalence and …
Roles of DNA repair enzyme OGG1 in innate immunity and its significance for lung cancer
S Vlahopoulos, M Adamaki, N Khoury… - Pharmacology & …, 2019 - Elsevier
Cytokines are pivotal mediators of the immune response, and their coordinated expression
protects host tissue from excessive damage and oxidant stress. Nevertheless, the …
protects host tissue from excessive damage and oxidant stress. Nevertheless, the …