The human connectome in Alzheimer disease—relationship to biomarkers and genetics
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …
resulting in cognitive impairment. The results of recent connectomics studies have now …
Imaging the evolution and pathophysiology of Alzheimer disease
W Jagust - Nature Reviews Neuroscience, 2018 - nature.com
Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …
studies of the relationships between the two major proteins deposited in this disease …
Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer's disease
Background: The only conclusive way to diagnose Alzheimer's is to carry out brain autopsy
of the patient's brain tissue and ascertain whether the subject had Alzheimer's or any other …
of the patient's brain tissue and ascertain whether the subject had Alzheimer's or any other …
[HTML][HTML] Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: update and areas of immediate need
Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging
population and society as a whole. With the numbers of people with ADRDs predicted to rise …
population and society as a whole. With the numbers of people with ADRDs predicted to rise …
Brain atrophy in Alzheimer's disease and aging
Thanks to its safety and accessibility, magnetic resonance imaging (MRI) is extensively used
in clinical routine and research field, largely contributing to our understanding of the …
in clinical routine and research field, largely contributing to our understanding of the …
APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer's disease: a systematic review
S Emrani, HA Arain, C DeMarshall, T Nuriel - Alzheimer's Research & …, 2020 - Springer
Possession of the ε4 allele of apolipoprotein E (APOE) is the primary genetic risk factor for
the sporadic form of Alzheimer's disease (AD). While researchers have extensively …
the sporadic form of Alzheimer's disease (AD). While researchers have extensively …
[PDF][PDF] Regional Aβ-tau interactions promote onset and acceleration of Alzheimer's disease tau spreading
Amyloid-beta and tau are key molecules in the pathogenesis of Alzheimer's disease, but it
remains unclear how these proteins interact to promote disease. Here, by combining cross …
remains unclear how these proteins interact to promote disease. Here, by combining cross …
Association of apolipoprotein E ε4 with medial temporal tau independent of amyloid-β
Importance Apolipoprotein E ε4 (APOEε4) is the single most important genetic risk factor for
Alzheimer disease. WhileAPOEε4is associated with increased amyloid-β burden, its …
Alzheimer disease. WhileAPOEε4is associated with increased amyloid-β burden, its …
Research criteria for the behavioral variant of Alzheimer disease: a systematic review and meta-analysis
R Ossenkoppele, EH Singleton, C Groot… - JAMA …, 2022 - jamanetwork.com
Importance The behavioral variant of Alzheimer disease (bvAD) is characterized by early
and predominant behavioral deficits caused by AD pathology. This AD phenotype is …
and predominant behavioral deficits caused by AD pathology. This AD phenotype is …
Characterizing brain cortical plasticity and network dynamics across the age-span in health and disease with TMS-EEG and TMS-fMRI
A Pascual-Leone, C Freitas, L Oberman, JC Horvath… - Brain topography, 2011 - Springer
Brain plasticity can be conceptualized as nature's invention to overcome limitations of the
genome and adapt to a rapidly changing environment. As such, plasticity is an intrinsic …
genome and adapt to a rapidly changing environment. As such, plasticity is an intrinsic …