Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for
proper brain development, function and circuitry formation in the mammalian central nervous …

Background Multiple studies have shown that brain gene expression is disturbed in subjects
suffering from schizophrenia. However, disentangling disease effects from alterations …

Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning.
Although defective alternative splicing has been linked to SZ, the molecular mechanisms …

Despite the strong genetic basis of psychiatric disorders, the underlying molecular
mechanisms are largely unmapped. RNA-binding proteins (RBPs) are responsible for most …

The prefrontal cortex is believed to play a major role in depression and suicidal behavior
through regulation of cognition, memory, recognition of emotion, and anxiety-like states, with …

Comprehensive analysis of the mammalian transcriptome has revealed that long non-
coding RNAs (lncRNAs) may make up a large fraction of cellular transcripts. Recent years …

Non-coding RNAs are emerging as regulatory RNAs that participate in the regulation of
gene expression and play vital roles in various biological and pathological processes. Long …

Background RNA-directed regulation of epigenetic processes has recently emerged as an
important feature of mammalian differentiation and development. Perturbation of this …

In the last 10 years, structural, molecular and functional changes in glial cells have become
a major focus of interest in the search for the neurobiological foundations of schizophrenia …

The quaking viable mouse mutation (qkv) is a deletion including the 5′ regulatory region of
the quaking gene (Qki), which causes body tremor and severe dysmyelination in mouse …