Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …

Next-generation sequencing has revealed that more than 50% of human cancers harbour
mutations in enzymes that are involved in chromatin organization. Tumour cells not only are …

The calcium signal is a powerful and multifaceted tool by which cells can achieve specific
outcomes. Cellular machinery important in tumour progression is often driven or influenced …

Summary Cyclin-dependent kinase 9 (CDK9) promotes transcriptional elongation through
RNAPII pause release. We now report that CDK9 is also essential for maintaining gene …

Calcium (Ca2+) signaling and the modulation of intracellular calcium ([Ca2+] i) levels play
critical roles in several key processes that regulate cellular survival, growth, differentiation …

Intracellular calcium (Ca2+) concentration ([Ca2+] i) is a key determinant of cell fate and is
implicated in carcinogenesis. Membrane ion channels are structures through which ions …

The fate of disseminated tumor cells is largely determined by microenvironment (ME) niche.
The osteogenic niche promotes cancer cell proliferation and bone metastasis progression …

Aberrant DNA methylation is a critically important modification in cancer cells, which,
through promoter and enhancer DNA methylation changes, use this mechanism to activate …

Calcium signaling plays an important role in gene expression. At the transcriptional level,
this may underpin mammalian neuronal synaptic plasticity. Calcium influx into the …

Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several
cardiac conditions and more recently have been recognized as potential antitumor …