Immunological considerations for COVID-19 vaccine strategies

M Jeyanathan, S Afkhami, F Smaill, MS Miller… - Nature Reviews …, 2020 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to …

The COVID-19 vaccine race: challenges and opportunities in vaccine formulation

J Wang, Y Peng, H Xu, Z Cui, RO Williams - Aaps Pharmscitech, 2020 - Springer
In the race for a safe and effective vaccine against coronavirus disease (COVID)-19,
pharmaceutical formulation science plays a critical role throughout the development …

[HTML][HTML] Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis

C Ding, R Shrestha, X Zhu, AE Geller, S Wu… - Nature …, 2023 - nature.com
Metastasis is the leading cause of cancer-related deaths and myeloid cells are critical in the
metastatic microenvironment. Here, we explore the implications of reprogramming pre …

Trained immunity: adaptation within innate immune mechanisms

J Domínguez-Andrés, JC Dos Santos… - Physiological …, 2023 - journals.physiology.org
The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …

Immunology of COVID‐19: mechanisms, clinical outcome, diagnostics, and perspectives—a report of the European Academy of Allergy and Clinical Immunology …

M Sokolowska, ZM Lukasik, I Agache, CA Akdis… - Allergy, 2020 - Wiley Online Library
With the worldwide spread of the novel severe acute respiratory syndrome coronavirus‐2
(SARS‐CoV‐2) resulting in declaration of a pandemic by the World Health Organization …

Human immunology and immunotherapy: main achievements and challenges

J Varadé, S Magadán… - Cellular & Molecular …, 2021 - nature.com
The immune system is a fascinating world of cells, soluble factors, interacting cells, and
tissues, all of which are interconnected. The highly complex nature of the immune system …

Analysis of COVID‐19 vaccines: types, thoughts, and application

X Han, P Xu, Q Ye - Journal of clinical laboratory analysis, 2021 - Wiley Online Library
Objective To deal with COVID‐19, various countries have made many efforts, including the
research and development of vaccines. The purpose of this manuscript was to summarize …

Vaccinology: time to change the paradigm?

CS Benn, AB Fisker, A Rieckmann, S Sørup… - The lancet infectious …, 2020 - thelancet.com
The existing vaccine paradigm assumes that vaccines only protect against the target
infection, that effective vaccines reduce mortality corresponding to the target infection's …

Intracellular pathogens: host immunity and microbial persistence strategies

A Thakur, H Mikkelsen… - Journal of immunology …, 2019 - Wiley Online Library
Infectious diseases caused by pathogens including viruses, bacteria, fungi, and parasites
are ranked as the second leading cause of death worldwide by the World Health …

A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens

J Yan, TB Nielsen, P Lu, Y Talyansky… - Science translational …, 2023 - science.org
Traditional vaccines are difficult to deploy against the diverse antimicrobial-resistant,
nosocomial pathogens that cause health care–associated infections. We developed a …