On the evolutionary origins of obesity: a new hypothesis

D Sellayah, FR Cagampang, RD Cox - Endocrinology, 2014 - academic.oup.com
Obesity is an escalating threat of pandemic proportions, currently affecting billions of people
worldwide and exerting a devastating socioeconomic influence in industrialized countries …

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases

AE Pravednikova, SY Shevchenko, VV Kerchev… - Molecular …, 2020 - Springer
The hereditary aspect of obesity is a major focus of modern medical genetics. The genetic
background is known to determine a higher-than-average prevalence of obesity in certain …

Meta-Analysis Reveals the Association of Common Variants in the Uncoupling Protein (UCP) 1–3 Genes with Body Mass Index Variability

LA Brondani, TS Assmann, BM de Souza, AP Boucas… - PloS one, 2014 - journals.plos.org
Background The relationship between uncoupling protein (UCP) 1–3 polymorphisms and
susceptibility to obesity has been investigated in several genetic studies. However, the …

Targeting mitochondrial impairment for the treatment of cardiovascular diseases: from hypertension to ischemia-reperfusion injury, searching for new pharmacological …

S Todisco, B Musio, V Pesce, MM Cavalluzzi… - Biochemical …, 2023 - Elsevier
Mitochondria and mitochondrial proteins represent a group of promising pharmacological
target candidates in the search of new molecular targets and drugs to counteract the onset of …

Brown adipose tissue: The heat is on the heart

R Thoonen, AG Hindle… - American Journal of …, 2016 - journals.physiology.org
The study of brown adipose tissue (BAT) has gained significant scientific interest since the
discovery of functional BAT in adult humans. The thermogenic properties of BAT are well …

Understanding the contemporary high obesity rate from an evolutionary genetic perspective

T Wu, S Xu - Hereditas, 2023 - Springer
The topic of obesity is gaining increasing popularity globally. From an evolutionary genetic
perspective, it is believed that the main cause of the high obesity rate is the mismatch …

The Presence of At Least Three Alleles of the ADRB3 Trp64Arg (C/T) and UCP1 −3826A/G Polymorphisms Is Associated with Protection to Overweight/Obesity and …

LA Brondani, GCK Duarte, LH Canani… - … Syndrome and Related …, 2014 - liebertpub.com
Background: We investigated whether the− 3826A/G polymorphism (rs1800592) of the
uncoupling protein 1 gene (UCP1) and the Trp64Arg polymorphism (rs4994) of the β3 …

The relationships between leptin, genotype, and Chinese medicine body constitution for obesity

HI Hou, HY Chen, JJ Lu, SC Chang… - Evidence‐Based …, 2021 - Wiley Online Library
Background and Purpose. Obesity is a widespread and increasingly severe problem
worldwide. Several single nucleotide polymorphisms (SNPs) associated with obesity have …

Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health

PC Dinas, E Nintou, M Vliora, AE Pravednikova… - Plos one, 2022 - journals.plos.org
Contribution of UCP1 single nucleotide polymorphisms (SNPs) to susceptibility for
cardiometabolic pathologies (CMP) and their involvement in specific risk factors for these …

Association of the UCP-1 single nucleotide polymorphism A-3826G with the dampness-phlegm pattern among Korean stroke patients

JH Lim, MM Ko, TW Moon, MH Cha, MS Lee - BMC complementary and …, 2012 - Springer
Background Patients with stroke have various syndromes and symptoms. Through pattern
identification (PI), traditional Korean medicine (TKM) classifies the several syndromes and …