The important role of GH in the control of mammalian longevity was first deduced from
extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with …

Aging is a global decline of physiological functions, leading to an increased susceptibility to
diseases and ultimately death. Maximum lifespans differ up to 200-fold between mammalian …

The regulation of energy homeostasis is controlled by the brain and, besides requiring high
amounts of energy, it relies on functional insulin/insulin‐like growth factor (IGF)‐1 signalling …

A number of studies performed on rodents suggest that insulin-like growth factor 2 (IGF-2) or
its analogs may possibly be used for treating some conditions like Alzheimer's disease …

Insulin receptor (IR) and insulin‐like growth factor 1 receptor (IGF 1R) are highly conserved
receptor tyrosine kinases that share signalling proteins and are ubiquitously expressed in …

The naked mole-rat (NMR) is a subterranean rodent that has gained significant attention
from the biomedical research community in recent years as molecular mechanisms …

Traditionally, the main mammalian models used in aging research have been mice and rats,
ie short-lived species that obviously lack effective maintenance mechanisms to keep their …

The insulin-like growth factors (IGFs; IGF1/IGF2), known for their regulation of cell and
organismal growth and development, are evolutionarily conserved ligands with equivalent …

Age-associated cognitive impairment is a major health and social issue because of
increasing aged population. Cognitive decline is not homogeneous in humans and the …

Mammals typically display a robust positive relationship between lifespan and body size.
Two groups that deviate markedly from this pattern are bats and African mole-rats, with …