Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and
triggers a bewildering array of both detrimental and beneficial effects in multiple …

Ventilatory responses to hypoxia vary widely depending on the pattern and length of hypoxic
exposure. Acute, prolonged, or intermittent hypoxic episodes can increase or decrease …

Spinal injury disrupts connections between the brain and spinal cord, causing life-long
paralysis. Most spinal injuries are incomplete, leaving spared neural pathways to motor …

Background. Neural plasticity may contribute to motor recovery following spinal cord injury
(SCI). In rat models of SCI with respiratory impairment, acute intermittent hypoxia (AIH) …

Intermittent hypoxia (IH) is most often thought of for its role in morbidity associated with sleep-
disordered breathing, including central nervous system pathology. However, recent …

In recent years, it has become clear that brief, repeated presentations of hypoxia [ie, acute
intermittent hypoxia (AIH)] can boost the efficacy of more traditional therapeutic strategies in …

As in other neural systems, plasticity is a hallmark of the neural system controlling breathing.
One spinal mechanism of respiratory plasticity is phrenic long‐term facilitation (pLTF) …

Although monosynaptic bulbospinal projections to phrenic motoneurons have been
extensively described, little is known about the organization of phrenic premotor neurons in …

Acute intermittent hypoxia [AIH; 3, 5-min episodes; 35–45 mmHg arterial Po2 (PaO2)] elicits
serotonin-dependent phrenic long-term facilitation (pLTF), a form of phrenic motor facilitation …

Plasticity is a hallmark of neural systems, including the neural system controlling breathing
(Mitchell and Johnson 2003). Despite its biological and potential clinical significance, our …