NANOBODIES®: A Review of Generation, Diagnostics and Therapeutics
B Jin, S Odongo, M Radwanska, S Magez - International journal of …, 2023 - mdpi.com
NANOBODY®(a registered trademark of Ablynx NV) molecules (Nbs), also referred to as
single domain-based VHHs, are antibody fragments derived from heavy-chain only IgG …
single domain-based VHHs, are antibody fragments derived from heavy-chain only IgG …
The therapeutic potential of nanobodies
I Jovčevska, S Muyldermans - BioDrugs, 2020 - Springer
Today, bio-medical efforts are entering the subcellular level, which is witnessed with the fast-
developing fields of nanomedicine, nanodiagnostics and nanotherapy in conjunction with …
developing fields of nanomedicine, nanodiagnostics and nanotherapy in conjunction with …
Applications of nanobodies
S Muyldermans - Annual review of animal biosciences, 2021 - annualreviews.org
Unique, functional, homodimeric heavy chain–only antibodies, devoid of light chains, are
circulating in the blood of Camelidae. These antibodies recognize their cognate antigen via …
circulating in the blood of Camelidae. These antibodies recognize their cognate antigen via …
A guide to: generation and design of nanobodies
S Muyldermans - The FEBS journal, 2021 - Wiley Online Library
A nanobody (Nb) is a registered trademark of Ablynx, referring to the single antigen‐binding
domain of heavy chain‐only antibodies (HCAbs) that are circulating in Camelidae. Nbs are …
domain of heavy chain‐only antibodies (HCAbs) that are circulating in Camelidae. Nbs are …
Nanobodies: natural single-domain antibodies
S Muyldermans - Annual review of biochemistry, 2013 - annualreviews.org
Sera of camelids contain both conventional heterotetrameric antibodies and unique
functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric …
functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric …
Immunogenicity and humanization of single‐domain antibodies
MA Rossotti, K Bélanger, KA Henry… - The FEBS Journal, 2022 - Wiley Online Library
Single‐domain antibodies (sdAbs), the autonomous variable domains of camelid and shark
heavy‐chain antibodies, have many desirable properties as components of biologic drugs …
heavy‐chain antibodies, have many desirable properties as components of biologic drugs …
Nanobodies: robust miniprotein binders in biomedicine
Variable domains of heavy chain-only antibodies (VHH), also known as nanobodies (Nbs),
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
An overview on display systems (phage, bacterial, and yeast display) for production of anticancer antibodies; advantages and disadvantages
Antibodies as ideal therapeutic and diagnostic molecules are among the top-selling drugs
providing considerable efficacy in disease treatment, especially in cancer therapy …
providing considerable efficacy in disease treatment, especially in cancer therapy …
General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold
Nanobodies, single-domain antigen-binding fragments of camelid-specific heavy-chain only
antibodies offer special advantages in therapy over classic antibody fragments because of …
antibodies offer special advantages in therapy over classic antibody fragments because of …
Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies
E De Genst, K Silence, K Decanniere… - Proceedings of the …, 2006 - National Acad Sciences
Clefts on protein surfaces are avoided by antigen-combining sites of conventional
antibodies, in contrast to heavy-chain antibodies (HCAbs) of camelids that seem to be …
antibodies, in contrast to heavy-chain antibodies (HCAbs) of camelids that seem to be …