The probabilistic model of Alzheimer disease: the amyloid hypothesis revised
The current conceptualization of Alzheimer disease (AD) is driven by the amyloid
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
Alzheimer's disease
In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …
[HTML][HTML] Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …
Amyloid-β-independent regulators of tau pathology in Alzheimer disease
R van der Kant, LSB Goldstein… - Nature Reviews …, 2020 - nature.com
The global epidemic of Alzheimer disease (AD) is worsening, and no approved treatment
can revert or arrest progression of this disease. AD pathology is characterized by the …
can revert or arrest progression of this disease. AD pathology is characterized by the …
[HTML][HTML] Alzheimer disease: an update on pathobiology and treatment strategies
JM Long, DM Holtzman - Cell, 2019 - cell.com
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …
The ageing brain: molecular and cellular basis of neurodegeneration
Ageing is an inevitable event in the lifecycle of all organisms, characterized by progressive
physiological deterioration and increased vulnerability to death. Ageing has also been …
physiological deterioration and increased vulnerability to death. Ageing has also been …
Towards a future where Alzheimer's disease pathology is stopped before the onset of dementia
WM van der Flier, ME de Vugt, EMA Smets, M Blom… - Nature aging, 2023 - nature.com
Alzheimer's disease (AD) is a major healthcare challenge with no curative treatment at
present. To address this challenge, we need a paradigm shift, where we focus on pre …
present. To address this challenge, we need a paradigm shift, where we focus on pre …
[HTML][HTML] Genetics of Alzheimer's disease: where we are, and where we are going
C Bellenguez, B Grenier-Boley, JC Lambert - Current opinion in …, 2020 - Elsevier
Highlights•More than 40 loci of interest have been associated with the risk of developing
AD.•Recent genetic data clearly implicate microglia as involved in the pathophysiological …
AD.•Recent genetic data clearly implicate microglia as involved in the pathophysiological …
Neuroimmune connections in aging and neurodegenerative diseases
In recent years, the inter-relationship between the innate immune system and the central
nervous system (CNS) has moved to the forefront of biomedical research, with the discovery …
nervous system (CNS) has moved to the forefront of biomedical research, with the discovery …
Translating genetic risk of Alzheimer's disease into mechanistic insight and drug targets
A Sierksma, V Escott-Price, B De Strooper - Science, 2020 - science.org
To provide better prevention and treatment, we need to understand the environmental and
genetic risks of Alzheimer's disease (AD). However, the definition of AD has been …
genetic risks of Alzheimer's disease (AD). However, the definition of AD has been …