Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids
in cells. PUFAs regulate cellular function through the formation of derived lipid mediators …

Platelets are essential for clotting in the blood and maintenance of normal hemostasis.
Under pathologic conditions such as atherosclerosis, vascular injury often results in …

ALOX12 encodes arachidonic acid 12-lipoxygenase that acts on different polyunsaturated
fatty acid substrates to produce biologically active lipid mediators including eicosanes and …

A significant amount of clinical and research interest in thrombosis is focused on large
vessels (eg, stroke, myocardial infarction, deep venous thrombosis, etc.); however …

Thrombosis is the most common underlying pathology responsible for morbidity and
mortality in cardiovascular disease (CVD). Platelet adhesion, activation, and aggregation …

Simple Summary Glioblastoma multiforme is a brain tumor with a very unfavorable
prognosis, where the vast majority of patients do not survive a year after diagnosis. One line …

Objective—Adequate platelet reactivity is required for maintaining hemostasis. However,
excessive platelet reactivity can also lead to the formation of occlusive thrombi. Platelet 12 …

In mammals, three major oxygenases, cyclooxygenases (COXs), lipoxygenases (LOXs), and
cytochrome P450 (CYP450), generate an assortment of unique lipid mediators (oxylipins) …

Platelet ACKR3/CXCR7 surface expression is enhanced and influences prognosis in
coronary artery disease (CAD) patients, who exhibit a distinct atherothrombotic platelet …

Antiplatelet therapy plays a critical role in the prevention and treatment of major
cardiovascular diseases triggered by thrombosis. Since the 1900s, significant progress in …