The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

The structure and integrity of telomeres are essential for genome stability. Telomere
dysregulation can lead to cell death, cell senescence, or abnormal cell proliferation. The …

Telomerase is the enzyme responsible for maintenance of the length of telomeres by
addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes …

The replication of the ends of linear chromosomes, or telomeres, poses unique problems,
which must be solved to maintain genome integrity and to allow cell division to occur. Here …

Human telomerase contains a 451 nt RNA (hTR) and several proteins, including a
specialized reverse transcriptase (hTERT). The 5′ half of hTR comprises the pseudoknot …

The physical ends of chromosomes, known as telomeres, protect chromosome ends from
nucleolytic degradation and DNA repair activities. Conventional DNA replication enzymes …

Telomerase is a ribonucleoprotein enzyme that extends DNA at the chromosome ends in
most eukaryotes. Since 1985, telomerase has been studied intensively and components of …

Maintenance of telomeres by the enzyme telomerase is essential for genomic stability and
cell viability in ciliates, vertebrates and yeast. The minimal components of telomerase …

Telomerase is the eukaryotic solution to the 'end-replication problem'of linear chromosomes
by synthesising the highly repetitive DNA constituent of telomeres, the nucleoprotein cap …

Asymmetric subcellular distribution of RNA is used by many organisms to establish cell
polarity, differences in cell fate, or to sequester protein activity. Accurate localization of RNA …