The blood–brain barrier (BBB) is a barrier that separates the blood from the brain tissue and
possesses unique characteristics that make the delivery of drugs to the brain a great …

Brain cancer, especially the most common type of glioblastoma, is highly invasive and
known as one of the most devastating and deadly neoplasms. Despite surgical and medical …

Blood–brain barrier (BBB) strictly controls matter exchange between blood and brain, and
severely limits brain penetration of systemically administered drugs, resulting in ineffective …

The blood-brain barrier (BBB) restricts the access of therapeutic agents to the brain,
complicating the treatment of neurological diseases, such as Alzheimer's disease (AD) …

Conventional chemotherapeutics exploration is hampered due to their nonspecific
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …

The current medical reality of cancer gene therapy is reflected by more than ten approved
products on the global market, including oncolytic and other viral vectors and CAR T-cells as …

Mycobacterium tuberculosis (MTB) is one of the most threatening pathogens for its latent
infection in macrophages. The intracellular MTB isolated itself from drugs and could spread …

Central nervous system (CNS) diseases are the leading causes of death and disabilities in
the world. It is quite challenging to treat CNS diseases efficiently because of the blood–brain …

Nanoparticles (NPs) are novel platforms that can carry both cancer-targeting molecules and
drugs to avoid severe side effects due to nonspecific drug delivery in standard …

The most common and aggressive primitive intracranial tumor of the central nervous system
is the glioma. The blood–brain barrier (BBB) has proven to be a significant obstacle to the …