Background Cuproptosis is a newly discovered unique non-apoptotic programmed cell
death distinguished from known death mechanisms like ferroptosis, pyroptosis, and …

The mammalian family of mitogen-activated protein kinases (MAPKs) includes extracellular
signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase (JNK), with each MAPK …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Sequential activation of kinases within the mitogen-activated protein (MAP) kinase (MAPK)
cascades is a common, and evolutionary-conserved mechanism of signal transduction. Four …

The extracellular signal-regulated kinase (ERK) cascade is a central pathway that transmits
signals from many extracellular agents to regulate cellular processes such as proliferation …

FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost
exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces …

Signaling complexes of MAPK module components can vary with time and location. Active
MAPKs frequently translocate from the cytoplasm to the nucleus to phosphorylate nuclear …

Sequential activation of protein kinases within the mitogen-activated protein kinase (MAPK)
cascades is a common mechanism of signal transduction in many cellular processes. Four …

The MAP kinases, discovered approximately 20 years ago, together with their immediate
upstream regulators, are among the most highly studied signal transduction molecules. This …

Mitogen-activated protein kinases (MAPKs) are members of a dynamic protein kinase
network through which diverse stimuli regulate the spatio-temporal activities of complex …