BRAF Mutation in Papillary Thyroid Cancer: Pathogenic Role, Molecular Bases, and Clinical Implications

M Xing - Endocrine reviews, 2007 - academic.oup.com
In recent years, the T1799A B-type Raf kinase (BRAF) mutation in thyroid cancer has
received enthusiastic investigation, and significant progress has been made toward …

Heterogeneity of thyroid cancer

E Chmielik, D Rusinek, M Oczko-Wojciechowska… - Pathobiology, 2018 - karger.com
There are 5 main histological types of thyroid cancers (TCs): papillary, follicular (also known
as differentiated), poorly differentiated, anaplastic (the most aggressive form), and medullary …

The prevalence and prognostic value of BRAF mutation in thyroid cancer

E Kebebew, J Weng, J Bauer, G Ranvier… - Annals of …, 2007 - journals.lww.com
Objective: To examine the prevalence of BRAF mutation among thyroid cancer histologic
subtypes and determine the association of BRAF mutation with indicators of poor prognosis …

[HTML][HTML] Risk factors for cervical lymph node metastasis in papillary thyroid microcarcinoma: a study of 1,587 patients

X Zheng, C Peng, M Gao, J Zhi, X Hou… - Cancer biology & …, 2019 - ncbi.nlm.nih.gov
Objective The purposes of this study were to identify risk factors for cervical lymph node
metastasis and to examine the association between BRAF V600E status and clinical …

Significance of multifocality in papillary thyroid carcinoma

JW Feng, Z Qu, AC Qin, H Pan, J Ye, Y Jiang - European Journal of …, 2020 - Elsevier
Background Although multifocality is often observed in papillary thyroid carcinoma (PTC),
the associations with clinicopathologic factors and the prognostic value are still …

[PDF][PDF] BRAF (V600E) mutation and the biology of papillary thyroid cancer

F Frasca, C Nucera, G Pellegriti, P Gangemi… - Endocrine-related …, 2008 - academia.edu
Abstract BRAF (V600E) mutation is the most frequent genetic alteration in papillary thyroid
carcinomas (PTCs) that are 80–90% of all thyroid cancers. We evaluated the relationship …

Multifocality, but not bilaterality, is a predictor of disease recurrence/persistence of papillary thyroid carcinoma

HJ Kim, SY Sohn, HW Jang, SW Kim… - World journal of …, 2013 - Wiley Online Library
Background Although papillary thyroid carcinoma (PTC) often presents as multifocal or
bilateral tumors, but whether multifocality or bilaterality is associated with disease …

BRAFV600E Mutation is Associated with Tumor Aggressiveness in Papillary Thyroid Cancer

S Kim, KE Lee, JP Myong, J Park, YK Jeon… - World journal of …, 2012 - Springer
Abstract Background The BRAF V600E mutation is the most common genetic alteration
found in papillary thyroid cancer (PTC). Recent studies show that this mutation occurs more …

BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications

KT Tang, CH Lee - Journal of the chinese medical association, 2010 - journals.lww.com
Papillary thyroid cancer (PTC) is the most common endocrine malignancy, accounting for 85–
90% of all thyroid cancers. Genetic alternations involving the mitogen-activated protein …

Multifocal papillary thyroid cancer increases the risk of central lymph node metastasis

A Al Afif, BA Williams, MH Rigby, MJ Bullock, SM Taylor… - Thyroid, 2015 - liebertpub.com
Background: Papillary thyroid cancer (PTC) is the most common thyroid malignancy, with a
strong predilection for lymph node metastasis, most commonly to the central neck …