The mammalian family of katanin microtubule-severing enzymes

NA Lynn, E Martinez, H Nguyen… - Frontiers in Cell and …, 2021 - frontiersin.org
The katanin family of microtubule-severing enzymes is critical for cytoskeletal
rearrangements that affect key cellular processes like division, migration, signaling, and …

Functional inhibition of katanin affects synaptic plasticity

FL Lombino, JR Schwarz, Y Pechmann… - Journal of …, 2024 - Soc Neuroscience
Dynamic microtubules critically regulate synaptic functions, but the role of microtubule
severing in these processes is barely understood. Katanin is a neuronally expressed …

SUMOylation of microtubule-cleaving enzyme KATNA1 promotes microtubule severing and neurite outgrowth

S Li, Y Liang, J Zou, Z Cai, H Yang, J Yang… - Journal of Biological …, 2022 - ASBMB
Katanin p60 ATPase-containing subunit A1 (KATNA1) is a microtubule-cleaving enzyme that
regulates the development of neural protrusions through cytoskeletal rearrangements …

Exploring purine analogues as inhibitors against Katanin, a microtubule severing enzyme using molecular modeling approach

V Saxena, P Patil, P Khodke, BV Kumbhar - Scientific Reports, 2024 - nature.com
Katanin, a key protein in cellular architecture, plays a crucial role in severing microtubules,
which are vital components of the cytoskeleton. Given its central involvement in cell division …

Effects of DISC1 on Alzheimer's disease cell models assessed by iTRAQ proteomics analysis

J Lu, R Huang, Y Peng, H Wang, Z Feng… - Bioscience …, 2022 - portlandpress.com
Alzheimer's disease (AD) is a form of neurodegenerative disease in the elderly with no cure
at present. In a previous study, we found that the scaffold protein, disrupted in Schizophrenia …

Whole-genome sequencing of cryopreserved resources from French Large White pigs at two distinct sampling times reveals strong signatures of convergent and …

S Boitard, L Liaubet, C Paris, K Fève, P Dehais… - Genetics Selection …, 2023 - Springer
Background Numerous genomic scans for positive selection have been performed in
livestock species within the last decade, but often a detailed characterization of the detected …

[图书][B] Investigating the spatial regulation mechanisms of the microtubule severing enzyme, Fidgetin-like 2

RL Birnbaum - 2023 - search.proquest.com
The cytoskeleton is a complex network of filaments necessary for many cellular functions,
broadly including division, differentiation, and motility. This network is made up of three …

Fertility is compromised after oocyte-specific deletion of Katanin A-subunit, Katna1, but not Katnal1

WS Yuen, QH Zhang, M Dunstan, D Aidhikari… - bioRxiv, 2023 - biorxiv.org
Katanins are microtubule severing enzymes that play roles in shaping diverse microtubule-
based structures during all cell cycle stages. To address the role of katanin A-subunits in …

[PDF][PDF] A key role for p60-Katanin in axon navigation is conditioned by the tubulin polyglutamylase TTLL6

D Ten Martin, N Jardin, F Giudicelli, L Gasmi… - bioRxiv, 2022 - scholar.archive.org
Selective interplay between microtubules and their regulatory proteins emerged as major
regulator of neuronal circuit development. However, how microtubule posttranslational …

Tubulin glutamylation is key to axon guidance via selective tuning of microtubule-severing enzymes

DT Martin, N Jardin, J Vougny, F Giudicelli, L Gasmi… - bioRxiv, 2022 - biorxiv.org
The microtubule cytoskeleton is a major driving force of neuronal circuit development. Fine-
tuned remodelling of this network by selective activation of microtubule-regulating proteins …