Abstract Purpose of Review The aim of this review is to summarize current conceptual
models of cognitive reserve (CR) and related concepts and to discuss evidence for these …

Neurological conditions, including cognitive impairment and Alzheimer's disease (AD),
impose a huge burden on society, affecting millions of people globally. In addition to genetic …

Chronic psychosocial stress is increasingly being recognised as a risk factor for sporadic
Alzheimer's disease (AD). The hypothalamic–pituitary–adrenal axis (HPA axis) is the major …

Importance The prevalence of dementia in Japan has been increasing. Childhood poverty
has been associated with increased risk of cognitive impairment, possibly mediated by …

Psychological stress is an emotion experienced when people are under mental pressure or
encounter unexpected problems. Extreme or repetitive stress increases the risk of …

Background: As adult brain structure is primarily established in early life, genetic and
environmental exposures in infancy and childhood influence the risk for Alzheimer disease …

Involvement of life stress in Late-Onset Alzheimer's Disease (LOAD) has been evinced in
longitudinal cohort epidemiological studies, and endocrinologic evidence suggests …

Objective To study the relation among psychosocial stressors, long-standing distress and
incidence of dementia, in a sample of women followed from midlife to late life. Design …

Background: Early-life environment is related to childhood brain development and cognitive
function in later life. However, the associations of early-life risk factors with dementia and …

Background Alzheimer's disease is a global health concern, and with no present cure,
prevention is critical. Exposure to adverse childhood experiences may increase the risk of …