Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and
synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central …

There is an epidemic of opioid use, abuse, and misuse in the United States, which results in
significant morbidity and mortality. It may be difficult to reduce perioperative opioid use given …

Abstract Purpose of Review Management of acute pain following surgery using a multimodal
approach is recommended by the American Society of Anesthesiologists whenever …

Background: Unexplained postoperative pain is one of the most feared complications of total
knee arthroplasty (TKA). A persistent noxious peripheral stimulus, such as the pain of …

Introduction The aim of this systematic review was to document efficacy, safety and quality of
evidence of analgesic interventions after total knee arthroplasty (TKA). Methods This …

In Australia and New Zealand, in parallel with other developed countries, the number of
patients prescribed opioids on a long-term basis has grown rapidly over the last decade …

This article reviews the current evidence for multimodal analgesic options for common
surgical procedures. As perioperative physicians, we have come a long way from using only …

Background Antidepressants are widely used in the treatment of chronic pain. Applied doses
are lower than those needed to unfold an antidepressive effect. While efficacy of …

Although certain risk factors can identify individuals who are most likely to develop chronic
pain, few interventions to prevent chronic pain have been identified. To facilitate the …

As surgical techniques and pharmacology advance, the management of postoperative pain
in patients undergoing total knee arthroplasty (TKA) continues to evolve. The current …