Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause
of cancer-related mortality rates worldwide. Although modern research was able to shed …

Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a
molecular lynchpin that links persistent infections and chronic inflammation to increased …

A delicate equilibrium of WNT agonists and antagonists in the intestinal stem cell (ISC) niche
is critical to maintaining the ISC compartment, as it accommodates the rapid renewal of the …

Adenomatous polyposis coli (APC) is widely accepted as a tumor suppressor gene highly
mutated in colorectal cancers (CRC). Mutation and inactivation of this gene is a key and …

An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the
underlying molecular mechanism remains undefined. Suspected risk factors of young onset …

The inherent complexity of multifactorial diseases such as cancer renders the process of
patient prognosis and prediction of response to therapy extremely difficult. Many markers …

The mutual and interdependent interaction between tumor and its microenvironment is a
crucial topic in cancer research. Recently, it was reported that targeting stromal events could …

This volume covers tumors of the pituary, the thyroid and parathyroid, the adrenal gland, the
endocrine pancreas, and inherited tumor syndromes. Each entity is extensively discussed …

Maintaining the chemical integrity of DNA in the face of assault by oxidizing agents is a
constant challenge for living organisms. Base-excision repair has an important role in …

Genetically modified animals are vital for gaining a proper understanding of disease
mechanisms. Mice have long been the mainstay of basic research into a wide variety of …