The entorhinal cortex (EC) is the brain region that often exhibits the earliest histological
alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and …

Rats and mice are used for studying neuronal circuits underlying recognition memory due to
their ability to spontaneously remember the occurrence of an object, its place and an …

In this review, we aim to reappraise the organization of intrinsic and extrinsic networks of the
entorhinal cortex with a focus on the concept of parallel cortical connectivity streams. The …

The hippocampal formation is critically involved in learning and memory and contains a
large proportion of neurons encoding aspects of the organism's spatial surroundings. In the …

The subregions of the entorhinal cortex (EC) are conventionally thought to compute
dichotomous representations for spatial processing, with the medial EC (MEC) providing a …

In this review we discuss converging evidence from human and rodent research
demonstrating how path integration (PI) is impaired in healthy aging and Alzheimer's …

The medial entorhinal cortex (MEC) creates a map of local space, based on the firing
patterns of grid, head-direction (HD), border, and object-vector (OV) cells. How these cell …

Locomotion activates an array of sensory inputs that may help build the self-position map of
the medial entorhinal cortex (MEC). In this map, speed-coding neurons are thought to …

Abnormally phosphorylated tau, an early neuropathologic marker of Alzheimer's disease
(AD), first occurs in the brain's entorhinal cortex layer II (ECII) and then spreads to the CA1 …

The medial entorhinal cortex (MEC) hosts many of the brain's circuit elements for spatial
navigation and episodic memory, operations that require neural activity to be organized …